Non-Cochrane · intervention · PM42598676
Non surgical periodontal therapy reduces gingival crevicular fluid adipocytokines and improves the clinical outcomes in chronic periodontitis patients with type 2 diabetes: A systematic review and meta-analysis.
Abraham Dax, Puri Aakansha, Mrinalini Mrinalini, et al. · Journal of Indian Society of Periodontology · 2026 · PubMed · doi:10.4103/jisp.jisp_230_25
Findings
11 findings
| Population | ||||
|---|---|---|---|---|
| Adults with chronic periodontitis and controlled type 2 diabetes | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | Periodontal probing depth (PPD) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices | SMC -2.95 [-4.51, -1.38] GRADE not reported 5 studies · 108 participants |
| Adults with chronic periodontitis and controlled type 2 diabetes | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | Plaque Index (PI) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices | SMC -5.04 [-7.11, -2.97] GRADE not reported 4 studies · 85 participants |
| Adults with chronic periodontitis and controlled type 2 diabetes | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | GCF adipocytokine levels (resistin, chemerin, leptin, visfatin; ELISA) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices · Sensitivity: Ahuja 2019 omitted | SMC -5.48 GRADE not reported 6 studies · 112 participants |
| Adults with chronic periodontitis and controlled type 2 diabetes | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | GCF adipocytokine levels (resistin, chemerin, leptin, visfatin; ELISA) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices | SMC -4.52 [-7.84, -1.20] GRADE not reported 7 studies · 142 participants |
| Adults with chronic periodontitis and controlled type 2 diabetes | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | Gingival Index (GI) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices | SMC -3.25 [-4.81, -1.69] GRADE not reported 5 studies · 108 participants |
| Adults with chronic periodontitis and controlled type 2 diabetes | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | Plaque Index (PI) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices · Sensitivity: GD 2023 omitted | SMC -6.13 [-7.17, -5.08] GRADE not reported 3 studies · 70 participants |
| Adults with chronic periodontitis and controlled type 2 diabetes | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | GCF adipocytokine levels (resistin, chemerin, leptin, visfatin; ELISA) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices · Sensitivity: GD 2023 omitted | SMC -3.69 GRADE not reported 6 studies · 127 participants |
| Adults with chronic periodontitis and controlled type 2 diabetes | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | Clinical attachment level (CAL) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices | SMC -2.36 [-3.88, -0.85] GRADE not reported 5 studies · 108 participants |
| Systemically healthy adults (healthy or chronic periodontitis without diabetes) comparator cohorts | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | GCF adipocytokine levels (resistin, chemerin, leptin, visfatin; ELISA) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices | SMC -0.17 [-1.10, 0.76] GRADE not reported 5 studies · 107 participants |
| Systemically healthy adults (healthy or chronic periodontitis without diabetes) comparator cohorts | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | GCF adipocytokine levels (resistin, chemerin, leptin, visfatin; ELISA) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices · Text-reported pooled value Unresolved: the two extractors disagree on this row. | SMC 0.259 [-0.66, 1.15] GRADE not reported 5 studies · 107 participants |
| Systemically healthy adults (healthy or chronic periodontitis without diabetes) comparator cohorts | Nonsurgical periodontal therapy (scaling and root planing) | Baseline (pretreatment) status | GCF adipocytokine levels (resistin, chemerin, leptin, visfatin; ELISA) Before versus after NSPT (follow-up 30 days to 6 months) · Clinical studies of GCF adipocytokines and periodontal indices · Sensitivity: Ahuja 2019 omitted | SMC -0.500 GRADE not reported 4 studies · 77 participants |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ahuja 2019 Effect of non-surgical periodontal treatment on gingival crevicular fluid and serum leptin levels in periodontally healthy chronic… PMID:31172690 | 2019 | 2 other reviews | not stated | not extracted yet |
| Dogan 2016 Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus. PMID:26991487 | 2016 | 1 other review | not stated | not extracted yet |
| Gomathi (GD) 2023 Effects of Non-surgical Periodontal Therapy on Saliva and Gingival Crevicular Fluid Levels of Chemerin in Periodontitis Subjects With and… PMID:36751175 | 2023 | 1 other review | not stated | not extracted yet |
| Mishra 2016 Interlinking Periodontitis and Type 2 Diabetes Mellitus by Assessment of Crevicular Visfatin Levels in Health and in Disease Before and… PMID:27656567 | 2016 | 1 other review | not stated | not extracted yet |
| Joshi 2019 Gingival crevicular fluid resistin levels in chronic periodontitis with type 2 diabetes before and after non-surgical periodontal therapy:… PMID:30900656 | 2019 | this review only | not stated | not extracted yet |
| Rode 2019 Relevance of single-nucleotide polymorphism to the expression of resistin gene affecting serum and gingival crevicular fluid resistin… PMID:30983784 | 2019 | this review only | not stated | not extracted yet |
| Wu 2015 Effect of non-surgical periodontal treatment on visfatin concentrations in serum and gingival crevicular fluid of patients with chronic… PMID:25786566 | 2015 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Nonobese adults (>=18 years) with chronic periodontitis and controlled type 2 diabetes mellitus | Chronic periodontitis with T2DM (n=142 in 7 studies); chronic periodontitis without diabetes comparator cohorts (n=107 in 5 studies) |
| Intervention | Nonsurgical periodontal treatment (scaling and root planing with standardized oral hygiene regimens) | Nonsurgical periodontal therapy (scaling and root planing) |
| Comparison | Baseline pretreatment status and, where available, systemically healthy chronic periodontitis cohorts receiving identical NSPT | Baseline pretreatment values (pre-post change) |
| Outcomes | GCF adipocytokine levels (resistin, chemerin, leptin, visfatin) by ELISA; periodontal clinical parameters | GCF leptin, chemerin, resistin, visfatin; clinical attachment level, plaque index, gingival index, probing depth |
| Study designs | RCTs, controlled clinical trials and observational studies | One randomized trial and six nonrandomized comparative studies (n=7) |
| Timing | Not specified | Follow-up 30 days to 6 months (Table 3) |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | Yes | Yes | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: Yes | RCT: Yes · NRSI: Yes | yes |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: No · NRSI: No | RCT: Partial Yes · NRSI: No | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | No | Yes | no |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | No | No | yes |
| Overall | Critically Low | Critically Low | yes |