Non-Cochrane · aetiology · PM42358973
Biomarkers for differentiating diabetic periodontitis from chronic periodontitis: a systematic review and meta-analysis.
Zhang Li, Li Ru, Zhang Shengnan, et al. · Frontiers in immunology · 2026 · PubMed · doi:10.3389/fimmu.2026.1758079
Findings
Population Patients with periodontitis; diabetes-related periodontitis (DMCP) group versus chronic periodontitis without diabetes (CP) group
67 findings
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Visfatin level | SMD 0.22 [-1.00, 1.43] GRADE not reported 3 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-10 level | SMD 0.04 [-0.58, 0.67] GRADE not reported 5 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | LDL cholesterol level | SMD 0.55 [-0.46, 1.57] GRADE not reported 5 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-23 level | SMD 0.19 [-0.17, 0.54] GRADE not reported 3 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | HDL cholesterol level | SMD -0.19 [-0.90, 0.51] GRADE not reported 5 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Reactive oxygen metabolites (ROM) level | SMD 1.28 [0.60, 1.97] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | RAGE level | SMD 0.01 [-0.50, 0.51] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Granulocyte colony-stimulating factor (G-CSF) level | SMD 0.37 [-0.22, 0.96] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-21 level | SMD 0.12 [-0.27, 0.50] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Total antioxidant capacity (TAOC) level Trim-and-fill adjusted for publication bias | Conclusion unchanged (not significant) after trim-and-fill; Begg P=0.035, Egger P=0.105. GRADE not reported Studies not reported |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-7 level | SMD 0.12 [-0.42, 0.66] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-8 level | SMD 0.38 [0.06, 0.70] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | RORC2 level | SMD -0.37 [-0.88, 0.15] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Monocyte chemoattractant protein-1 (MCP-1) level | SMD -0.29 [-0.88, 0.29] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Transforming growth factor beta level | SMD 0.27 [-0.06, 0.61] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Plasminogen activator inhibitor-1 (PAI-1) level | SMD 3.80 [3.07, 4.53] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-4 level Trim-and-fill adjusted for publication bias | Conclusion unchanged (not significant) after trim-and-fill; Egger P=0.003. GRADE not reported Studies not reported |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-4 level | SMD -0.62 [-1.37, 0.13] GRADE not reported 5 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Tumor necrosis factor alpha level Trim-and-fill adjusted for publication bias | No longer significant after trim-and-fill; Egger P=0.004, Begg P=0.251. GRADE not reported Studies not reported |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Oxidized glutathione (GSSG) level | SMD -1.16 [-1.76, -0.55] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Body mass index (BMI) level Trim-and-fill adjusted for publication bias | Remained significant after trim-and-fill; publication bias indicated. GRADE not reported Studies not reported |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Glucagon-like peptide-1 (GLP-1) level | SMD 3.66 [2.94, 4.37] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interferon gamma level | SMD 0.28 [-0.28, 0.83] GRADE not reported 4 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | RANKL level | SMD 0.55 [-0.18, 1.27] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-1 beta level | SMD 0.29 [-0.45, 1.03] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | 8-isoprostane level | SMD -0.25 [-0.75, 0.26] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Nitric oxide synthase (NOS) level | SMD 0.58 [0.11, 1.05] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Total cholesterol level | SMD 0.65 [-0.35, 1.65] GRADE not reported 5 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Catalase (CAT) level | SMD -0.31 [-0.58, -0.05] GRADE not reported 4 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Leptin level | SMD 2.33 [-1.80, 6.46] GRADE not reported 3 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Glutathione reductase (GR) level | SMD 0.33 [-0.18, 0.84] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | VLDL cholesterol level | SMD 0.91 [0.43, 1.39] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-13 level | SMD 3.15 [-3.02, 9.33] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Tissue inhibitor of metalloproteinase-3 (TIMP-3) level | SMD 0.87 [0.14, 1.60] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Eotaxin level | SMD 2.26 [1.51, 3.01] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Macrophage inflammatory protein-1 alpha (MIP-1a) level | SMD 0.97 [-0.10, 2.03] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Ghrelin level | SMD 0.03 [-0.42, 0.47] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Granulocyte-macrophage colony-stimulating factor (GM-CSF) level | SMD 0.60 [-0.72, 1.93] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Superoxide dismutase (SOD) level | SMD 0.90 [-0.26, 2.07] GRADE not reported 5 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Glucose-dependent insulinotropic polypeptide (GIP) level | SMD 6.50 [5.41, 7.59] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-6 level Trim-and-fill adjusted for publication bias | No significant difference after trim-and-fill; Egger P=0.005, Begg P=0.019. GRADE not reported Studies not reported |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Oxidative stress index (OSI) level | SMD 0.22 [-0.40, 0.84] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | 25-hydroxyvitamin D [25(OH)D] level | SMD -0.57 [-0.98, -0.15] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Total antioxidant capacity (TAOC) level | SMD -0.50 [-1.30, 0.30] GRADE not reported 7 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Uric acid level | SMD 0.35 [-0.07, 0.77] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Tumor necrosis factor alpha level | SMD 0.88 [0.10, 1.66] GRADE not reported 6 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Toll-like receptor 2 level | SMD 0.04 [-0.47, 0.54] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | High-sensitivity C-reactive protein level | SMD 2.56 [0.31, 4.82] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Osteoprotegerin level | SMD 0.19 [-0.48, 0.86] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-12 level | SMD 0.74 [-1.02, 2.51] GRADE not reported 2 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Triglycerides level | SMD 1.18 [0.20, 2.15] GRADE not reported 5 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Tissue inhibitor of metalloproteinase-4 (TIMP-4) level | SMD 0.90 [0.17, 1.63] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | C-peptide level | SMD -6.69 [-7.81, -5.58] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-6 level | SMD 1.16 [0.06, 2.25] GRADE not reported 6 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Second mitochondria-derived activator of caspase (SMAC) level | SMD -0.53 [-1.16, 0.10] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-17 level | SMD 0.28 [-0.25, 0.81] GRADE not reported 3 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Glucagon level | SMD 2.20 [1.64, 2.76] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Stem cell factor (SCF) level | SMD 2.41 [1.45, 3.36] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Body mass index (BMI) level | SMD 1.13 [0.21, 2.04] GRADE not reported 7 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | 4-hydroxynonenal (4-HNE) level | SMD 7.05 [5.07, 9.03] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Malondialdehyde (MDA) level | SMD 0.12 [-0.59, 0.84] GRADE not reported 3 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Glutathione (GSH) level | SMD 0.07 [-0.74, 0.87] GRADE not reported 3 studies |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-5 level | SMD 0.00 [-0.39, 0.38] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Toll-like receptor 4 level | SMD -0.32 [-0.83, 0.19] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Total oxidant status (TOS) level | SMD 0.28 [-0.34, 0.90] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Foxp3 level | SMD -0.15 [-0.66, 0.35] GRADE not reported 1 study |
| Diabetes-related periodontitis (DMCP; periodontitis in patients with type 2 diabetes) | Chronic periodontitis without diabetes (CP) | Interleukin-2 level | SMD -0.47 [-1.53, 0.59] GRADE not reported 2 studies |
Included primary studies 33
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ahuja 2019 Effect of non-surgical periodontal treatment on gingival crevicular fluid and serum leptin levels in periodontally healthy chronic… PMID:31172690 | 2019 | 2 other reviews | not stated | not extracted yet |
| Kardesler 2010 Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. PMID:20059414 | 2010 | 1 other review | not stated | not extracted yet |
| Acharya 2015 Effect of scaling and root planing on serum interleukin-10 levels and glycemic control in chronic periodontitis and type 2 diabetes… PMID:26015670 | 2015 | this review only | not stated | not extracted yet |
| Acharya 2018 Systemic Cytokines in Type 2 Diabetes Mellitus and Chronic Periodontitis. PMID:28000545 | 2018 | this review only | not stated | not extracted yet |
| Akalın 2008 Superoxide dismutase activity in gingiva in type-2 diabetes mellitus patients with chronic periodontitis. PMID:17880913 | 2008 | this review only | not stated | not extracted yet |
| Allen 2011 Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. PMID:21883360 | 2011 | this review only | not stated | not extracted yet |
| Bakshi 2018 Estimation of Plasma Levels of Tumor Necrosis Factor-a, Interleukin-4 and 6 in Patients with Chronic Periodontitis and Type II Diabetes… PMID:29422465 | 2018 | this review only | not stated | not extracted yet |
| Duarte 2012 Expression of immune-inflammatory markers in sites of chronic periodontitis in patients with type 2 diabetes. PMID:21859322 | 2012 | this review only | not stated | not extracted yet |
| Duarte 2014 Local levels of inflammatory mediators in uncontrolled type 2 diabetic subjects with chronic periodontitis. PMID:24206042 | 2014 | this review only | not stated | not extracted yet |
| Ghallab 2015 Expression of Leptin and Visfatin in Gingival Tissues of Chronic Periodontitis With and Without Type 2 Diabetes Mellitus: A Study Using… PMID:25811944 | 2015 | this review only | not stated | not extracted yet |
| Gumus 2009 Salivary antioxidants in patients with type 1 or 2 diabetes and inflammatory periodontal disease: a case-control study. PMID:19722794 | 2009 | this review only | not stated | not extracted yet |
| Guo 2018 Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus. PMID:29636044 | 2018 | this review only | not stated | not extracted yet |
| Joseph 2015 Low levels of serum Vitamin D in chronic periodontitis patients with type 2 diabetes mellitus: A hospital-based cross-sectional clinical… PMID:26644714 | 2015 | this review only | not stated | not extracted yet |
| Jung 2013 The expression of a nitric oxide derivative, tissue inhibitors of metalloproteinase-3, and tissue inhibitors of metalloproteinase-4 in… PMID:23678392 | 2013 | this review only | not stated | not extracted yet |
| Kalra 2013 Association of stem cell factor and high-sensitivity C reactive protein concentrations in crevicular fluid and serum in patients with… PMID:23485602 | 2013 | this review only | not stated | not extracted yet |
| Koregol 2018 8-Isoprostane in chronic periodontitis and type II diabetes: Exploring the link. PMID:30774790 | 2018 | this review only | not stated | not extracted yet |
| Lobão 2024 Redox biomarkers in saliva and nuclear abnormalities in jugal epithelial cells of individuals with type 2 diabetes mellitus and… PMID:38412774 | 2024 | this review only | not stated | not extracted yet |
| Miranda 2019 The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2… PMID:29737428 | 2019 | this review only | not stated | not extracted yet |
| Mohamed 2015 Impact of Chronic Periodontitis on Levels of Glucoregulatory Biomarkers in Gingival Crevicular Fluid of Adults with and without Type 2… PMID:25993052 | 2015 | this review only | not stated | not extracted yet |
| Patil 2016 Chronic Periodontitis in Type 2 Diabetes Mellitus: Oxidative Stress as a Common Factor in Periodontal Tissue Injury. PMID:27190790 | 2016 | this review only | not stated | not extracted yet |
| Pendyala 2013 Evaluation of Total Antioxidant Capacity of Saliva in Type 2 Diabetic Patients with and without Periodontal Disease: A Case-Control Study. PMID:23378957 | 2013 | this review only | not stated | not extracted yet |
| Pradeep 2012 Association of serum and crevicular visfatin levels in periodontal health and disease with type 2 diabetes mellitus. PMID:21966944 | 2012 | this review only | not stated | not extracted yet |
| Pradeep 2013 4-Hydroxy-2-nonenal, an oxidative stress marker in crevicular fluid and serum in type 2 diabetes with chronic periodontitis. PMID:24124291 | 2013 | this review only | not stated | not extracted yet |
| Ribeiro 2011 Cytokines and bone-related factors in systemically healthy patients with chronic periodontitis and patients with type 2 diabetes and… PMID:21284550 | 2011 | this review only | not stated | not extracted yet |
| Sangappa 2024 Salivary Interleukin-6 as a Non-Invasive Biomarker for Chronic Periodontitis and Tooth Loss in Type 2 Diabetes. PMID:38934745 | 2024 | this review only | not stated | not extracted yet |
| Shaker 2013 Inducible nitric oxide synthase (iNOS) in gingival tissues of chronic periodontitis with and without diabetes: immunohistochemistry and… PMID:23830615 | 2013 | this review only | not stated | not extracted yet |
| Shee 2020 Cellular and Biochemical Changes in Different Categories of Periodontitis: A Patient-based Study. PMID:32802782 | 2020 | this review only | not stated | not extracted yet |
| Sudhakar 2015 Opioid exposure after injury in United States trauma centers: A prospective, multicenter observational study. PMID:32459447 | 2020 | this review only | not stated | not extracted yet |
| Thomas 2013 A comparative evaluation of antioxidant enzymes and selenium in the serum of periodontitis patients with diabetes mellitus type 2. PMID:24015005 | 2013 | this review only | not stated | not extracted yet |
| Thomas 2014 Serum levels of antioxidants and superoxide dismutase in periodontitis patients with diabetes type 2. PMID:25210258 | 2014 | this review only | not stated | not extracted yet |
| Thomas 2021 Assessment of the antioxidant levels in sera of periodontitis patients with or without diabetes mellitus DOI:10.5958/0974-360x.2021.00183.9 | 2021 | this review only | not stated | not extracted yet |
| Trivedi 2014 Evaluation of antioxidant enzymes activity and malondialdehyde levels in patients with chronic periodontitis and diabetes mellitus. PMID:23895253 | 2014 | this review only | not stated | not extracted yet |
| Vincent 2018 Oxidative stress in chronic periodontitis patients with type II diabetes mellitus. PMID:29988233 | 2018 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with a confirmed diagnosis of diabetes-related periodontitis (DMCP) and patients with chronic periodontitis (CP) | Patients with periodontitis, type 2 diabetes (DMCP n=970) vs without diabetes (CP n=905) |
| Intervention | Exposure: diabetes-related periodontitis (DMCP) | DMCP (n=970) |
| Comparison | Chronic periodontitis without diabetes (CP) | CP (n=905) |
| Outcomes | Expression levels of biomarkers in both patient groups | Lipid profiles; inflammatory factors and mediators; oxidative stress-related biomarkers; other biomarkers (SMD of biomarker levels) |
| Study designs | Published cross-sectional, case-control or cohort studies | 33 cross-sectional studies |
| Timing | Not specified | Not specified |