Non-Cochrane · prognostic · PM41413925
The Effect of Diabetes on Outcomes of Non-Surgical Periodontal Therapy: A Systematic Review With a Meta-Analysis and Trial Sequential Analysis.
Weijdijk L P M, Thomassen T M J A, de Keyzer N C, et al. · International journal of dental hygiene · 2026 · PubMed · doi:10.1111/idh.70003
Findings
57 findings
| Population | ||||
|---|---|---|---|---|
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Plaque score (%) Baseline · Clinical, NSPT | MD 3.69 [-3.88, 11.25] Moderate Downgraded: publication bias 17 studies · 594 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Probing pocket depth (PPD, mm) Post-NSPT (longest follow-up within 1 year) · Clinical, NSPT | MD 0.16 [0.03, 0.29] Moderate Downgraded: publication bias 32 studies · 1259 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Gingival recession (REC, mm) Baseline · Clinical, NSPT | MD 0.22 [-0.11, 0.56] Moderate Downgraded: publication bias 4 studies · 89 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM) | Periodontitis patients without diabetes (NDM) | Gingival index (GI, Loe and Silness 1963) Incremental change (end minus baseline) · Overall (any diabetes mellitus) | MD 0.01 [-0.11, 0.13] Moderate Downgraded: publication bias 7 studies · 316 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Clinical attachment level (CAL, mm) Baseline · Clinical, NSPT | MD 0.27 [0.13, 0.41] Moderate Downgraded: publication bias 27 studies · 1060 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Gingival recession (REC, mm) Post-NSPT (longest follow-up within 1 year) · Clinical, NSPT | MD 0.05 [-0.49, 0.60] Moderate Downgraded: publication bias 4 studies · 89 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Plaque index (Silness & Loe) Baseline · Clinical, NSPT | MD 0.03 [-0.09, 0.16] Moderate Downgraded: publication bias 15 studies · 682 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Plaque index (Silness & Loe) Post-NSPT (longest follow-up within 1 year) · Clinical, NSPT | MD 0.07 [-0.06, 0.19] Moderate Downgraded: publication bias 15 studies · 682 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Plaque score (%) Post-NSPT (longest follow-up within 1 year) · Clinical, NSPT | MD -0.48 [-7.65, 6.70] Moderate Downgraded: publication bias 17 studies · 591 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Gingival bleeding index (Ainamo & Bay, %) Post-NSPT (longest follow-up within 1 year) · Clinical, NSPT | MD 1.57 [-0.05, 3.18] Moderate Downgraded: publication bias 9 studies · 286 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM) | Periodontitis patients without diabetes (NDM) | Plaque index (PI, Silness and Loe 1964) Incremental change (end minus baseline) · Overall (any diabetes mellitus) | MD -0.28 [-0.80, 0.23] Moderate Downgraded: publication bias 4 studies · 193 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM) | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Incremental change (end minus baseline) · Overall (any diabetes mellitus) | MD 0.02 [-0.06, 0.10] Moderate Downgraded: publication bias 21 studies · 772 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Probing pocket depth (PPD, mm) Baseline · Clinical, NSPT | MD 0.21 [0.07, 0.35] Moderate Downgraded: publication bias 32 studies · 1261 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Clinical attachment level (CAL, mm) Post-NSPT (longest follow-up within 1 year) · Clinical, NSPT | MD 0.26 [0.05, 0.47] Moderate Downgraded: publication bias 27 studies · 1058 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM) | Periodontitis patients without diabetes (NDM) | Gingival recession (REC) Incremental change (end minus baseline) · Overall (any diabetes mellitus) | MD -0.10 [-0.27, 0.06] Moderate Downgraded: publication bias 3 studies · 58 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Gingival bleeding index (Ainamo & Bay, %) Baseline · Clinical, NSPT | MD 1.81 [-4.03, 7.64] Moderate Downgraded: publication bias 9 studies · 286 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Bleeding on probing (BOP, %) Baseline · Clinical, NSPT | MD 0.38 [-8.01, 8.77] Moderate Downgraded: publication bias 14 studies · 521 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM) | Periodontitis patients without diabetes (NDM) | Gingival bleeding index (GBI, Ainamo and Bay 1975) Incremental change (end minus baseline) · Overall (any diabetes mellitus) | MD -17.94 [-40.62, 4.73] Moderate Downgraded: publication bias 4 studies · 129 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Gingival index (Loe & Silness) Baseline · Clinical, NSPT | MD 0.13 [0.05, 0.22] Moderate Downgraded: publication bias 17 studies · 772 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Gingival index (Loe & Silness) Post-NSPT (longest follow-up within 1 year) · Clinical, NSPT | MD 0.18 [0.10, 0.25] Moderate Downgraded: publication bias 17 studies · 772 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM) | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Incremental change (end minus baseline) · Overall (any diabetes mellitus) | MD -0.06 [-0.19, 0.07] Moderate Downgraded: publication bias 18 studies · 701 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM) | Periodontitis patients without diabetes (NDM) | Bleeding on probing (BOP, %) Incremental change (end minus baseline) · Overall (any diabetes mellitus) | MD 4.39 [-3.94, 12.71] Moderate Downgraded: publication bias 13 studies · 491 participants |
| Adults with periodontitis receiving non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), any type, any control (exposure) | Periodontitis patients without DM (NDM) | Bleeding on probing (BOP, %) Post-NSPT (longest follow-up within 1 year) · Clinical, NSPT | MD 4.64 [1.39, 7.89] Moderate Downgraded: publication bias 14 studies · 521 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM) | Periodontitis patients without diabetes (NDM) | Plaque score (%) Incremental change (end minus baseline) · Overall (any diabetes mellitus) | MD -2.80 [-6.47, 0.87] Moderate Downgraded: publication bias 14 studies · 474 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Well controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Incremental change (end minus baseline) · Well controlled DM | MD 0.06 [-0.04, 0.16] GRADE not reported 6 studies · 287 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Well controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Incremental change (end minus baseline) · Well controlled DM | MD 0.03 [-0.07, 0.14] GRADE not reported 7 studies · 315 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Well controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Baseline · Well controlled DM | MD 0.23 [0.05, 0.42] GRADE not reported 14 studies · 659 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Well controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) End (post-NSPT) · Well controlled DM | MD 0.22 [0.07, 0.37] GRADE not reported 12 studies · 528 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Well controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) End (post-NSPT) · Well controlled DM | MD 0.15 [0.03, 0.26] GRADE not reported 14 studies · 658 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Well controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Baseline · Well controlled DM | MD 0.23 [0.08, 0.38] GRADE not reported 12 studies · 529 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Poorly controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Incremental change (end minus baseline) · Poorly controlled DM | MD 0.08 [0.02, 0.14] GRADE not reported 5 studies · 213 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Poorly controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) End (post-NSPT) · Poorly controlled DM | MD 0.15 [-0.01, 0.32] GRADE not reported 8 studies · 327 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Poorly controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) End (post-NSPT) · Poorly controlled DM | MD 0.20 [-0.01, 0.42] GRADE not reported 8 studies · 327 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Poorly controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Baseline · Poorly controlled DM | MD 0.14 [-0.23, 0.51] GRADE not reported 8 studies · 328 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Poorly controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Baseline · Poorly controlled DM | MD 0.14 [-0.09, 0.38] GRADE not reported 8 studies · 328 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Poorly controlled diabetes mellitus | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Incremental change (end minus baseline) · Poorly controlled DM | MD 0.07 [-0.06, 0.21] GRADE not reported 5 studies · 213 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), deep pockets | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Incremental change (end minus baseline) · Deep pockets (>=7 mm) | MD 0.34 [-0.94, 1.62] GRADE not reported 3 studies · 142 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), deep pockets | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Baseline · Deep pockets (>=7 mm) | MD 1.41 [-0.53, 3.35] GRADE not reported 4 studies · 173 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), deep pockets | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) End (post-NSPT) · Deep pockets (>=7 mm) | MD 1.21 [-0.25, 2.67] GRADE not reported 4 studies · 173 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), European studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Incremental change (end minus baseline) · Studies from Europe | MD -0.02 [-0.23, 0.19] GRADE not reported 8 studies · 245 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), European studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) End (post-NSPT) · Studies from Europe | MD 0.24 [-0.14, 0.62] GRADE not reported 12 studies · 361 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), European studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Incremental change (end minus baseline) · Studies from Europe | MD 0.08 [0.01, 0.16] GRADE not reported 8 studies · 245 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), European studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Baseline · Studies from Europe | MD 0.22 [-0.02, 0.45] GRADE not reported 12 studies · 361 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), European studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Baseline · Studies from Europe | MD -0.01 [-0.22, 0.20] GRADE not reported 12 studies · 361 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), European studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) End (post-NSPT) · Studies from Europe | MD 0.03 [-0.17, 0.23] GRADE not reported 12 studies · 361 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), Asian studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Baseline · Studies from Asia | MD 0.46 [0.27, 0.64] GRADE not reported 12 studies · 574 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), Asian studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Incremental change (end minus baseline) · Studies from Asia | MD -0.02 [-0.13, 0.09] GRADE not reported 3 studies · 163 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), Asian studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) End (post-NSPT) · Studies from Asia | MD 0.21 [-0.00, 0.42] GRADE not reported 7 studies · 373 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), Asian studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Incremental change (end minus baseline) · Studies from Asia | MD 0.13 [-0.11, 0.37] GRADE not reported 6 studies · 234 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), Asian studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Baseline · Studies from Asia | MD 0.25 [0.05, 0.46] GRADE not reported 7 studies · 373 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), Asian studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) End (post-NSPT) · Studies from Asia | MD 0.28 [0.11, 0.45] GRADE not reported 12 studies · 574 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), South American studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Baseline · Studies from South America | MD 0.41 [0.08, 0.74] GRADE not reported 8 studies · 326 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), South American studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) End (post-NSPT) · Studies from South America | MD 0.32 [0.05, 0.60] GRADE not reported 8 studies · 324 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), South American studies | Periodontitis patients without diabetes (NDM) | Clinical attachment level (CAL) Incremental change (end minus baseline) · Studies from South America | MD -0.13 [-0.32, 0.05] GRADE not reported 7 studies · 293 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), South American studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Incremental change (end minus baseline) · Studies from South America | MD -0.18 [-0.34, -0.03] GRADE not reported 7 studies · 293 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), South American studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) End (post-NSPT) · Studies from South America | MD 0.20 [0.04, 0.37] GRADE not reported 8 studies · 324 participants |
| Periodontitis patients undergoing non-surgical periodontal therapy (NSPT) | Diabetes mellitus (DM), South American studies | Periodontitis patients without diabetes (NDM) | Probing pocket depth (PPD) Baseline · Studies from South America | MD 0.28 [-0.11, 0.67] GRADE not reported 8 studies · 326 participants |
Included primary studies 32
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ahuja 2019 Effect of non-surgical periodontal treatment on gingival crevicular fluid and serum leptin levels in periodontally healthy chronic… PMID:31172690 | 2019 | 2 other reviews | not stated | not extracted yet |
| Dogan 2016 Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus. PMID:26991487 | 2016 | 1 other review | not stated | not extracted yet |
| Gomathi 2023 Effects of Non-surgical Periodontal Therapy on Saliva and Gingival Crevicular Fluid Levels of Chemerin in Periodontitis Subjects With and… PMID:36751175 | 2023 | 1 other review | not stated | not extracted yet |
| Kardesler 2010 Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. PMID:20059414 | 2010 | 1 other review | not stated | not extracted yet |
| Mishra 2016 Interlinking Periodontitis and Type 2 Diabetes Mellitus by Assessment of Crevicular Visfatin Levels in Health and in Disease Before and… PMID:27656567 | 2016 | 1 other review | not stated | not extracted yet |
| Abreu 2016 Gingival crevicular fluid levels of protease-activated receptors type 1 and type 2 in diabetic patients with periodontitis. PMID:26564991 | 2016 | this review only | not stated | not extracted yet |
| Almeida 2020 Effects of a full-mouth disinfection protocol on the treatment of type-2 diabetic and non-diabetic subjects with mild-to-moderate… PMID:31102044 | 2020 | this review only | not stated | not extracted yet |
| Buzinin 2014 Effects of nonsurgical periodontal therapy on clinical response, microbiological profile, and glycemic control in Malaysian subjects with… PMID:25147841 | 2014 | this review only | not stated | not extracted yet |
| Camargo 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Camargo 2013 Effect of periodontal therapy on metabolic control and levels of IL-6 in the gingival crevicular fluid in type 2 diabetes mellitus. PMID:23852243 | 2013 | this review only | not stated | not extracted yet |
| Christgau 1998 Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunologic results. PMID:9495610 | 1998 | this review only | not stated | not extracted yet |
| Cirano 2012 Clinical and metabolic evaluation of one-stage, full-mouth, ultrasonic debridement as a therapeutic approach for uncontrolled type 2… PMID:23034420 | 2012 | this review only | not stated | not extracted yet |
| Correa 2008 The Short‐Term Effectiveness of Non‐Surgical Treatment in Reducing Levels of Interleukin‐1β and Proteases in Gingival Crevicular Fluid… DOI:10.1902/jop.2008.080132 | 2008 | this review only | not stated | not extracted yet |
| da Cruz 2008 Clinical and laboratory evaluations of non-surgical periodontal treatment in subjects with diabetes mellitus. PMID:18597596 | 2008 | this review only | not stated | not extracted yet |
| Dag 2009 The effect of periodontal therapy on serum TNF-alpha and HbA1c levels in type 2 diabetic patients. PMID:19228128 | 2009 | this review only | not stated | not extracted yet |
| Gayathri 2019 Effect of Initial Periodontal Therapy on Serum Nitric Oxide Levels in Chronic Periodontitis Patients with or without Type 2 Diabetes… PMID:31058635 | 2019 | this review only | not stated | not extracted yet |
| Goncalves 2008 The effect of non-surgical periodontal therapy on peroxidase activity in diabetic patients: a case-control pilot study. PMID:18651848 | 2008 | this review only | not stated | not extracted yet |
| Hungund 2012 Reduction in HbA1c levels following non-surgical periodontal therapy in type-2 diabetic patients with chronic generalized periodontitis: A… PMID:22628957 | 2012 | this review only | not stated | not extracted yet |
| Kara 2015 Short term effects of periodontal therapy on inflammatory markers in patients with type-2 diabetes. PMID:25828285 | 2015 | this review only | not stated | not extracted yet |
| Kaur 2015 Periodontal and glycemic effects of nonsurgical periodontal therapy in patients with type 2 diabetes stratified by baseline HbA1c. PMID:26369484 | 2015 | this review only | not stated | not extracted yet |
| Kudva 2010 Evaluation of clinical and metabolic changes after non surgical periodontal treatment of type 2 diabetes mellitus patients: A clinico… PMID:21731253 | 2010 | this review only | not stated | not extracted yet |
| Lopez 2014 Routine prophylaxes every 3 months improves chronic periodontitis status in type 2 diabetes. PMID:24354651 | 2014 | this review only | not stated | not extracted yet |
| Mirnic 2021 Clinical and Microbiological Assessment of Non-Surgical Treatment of Chronic Periodontitis in Controlled and Uncontrolled Type 2 Diabetic… DOI:10.20471/acc.2021.60.03.10 | 2021 | this review only | not stated | not extracted yet |
| Mirnic 2021 CLINICAL AND MICROBIOLOGICAL ASSESSMENT OF NON-SURGICAL TREATMENT OF CHRONIC PERIODONTITIS IN CONTROLLED AND UNCONTROLLED TYPE 2 DIABETIC… PMID:35282487 | 2022 | this review only | not stated | not extracted yet |
| Navarro-Sanchez 2007 Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with… PMID:17850602 | 2007 | this review only | not stated | not extracted yet |
| Pannicker 2016 Effects of scaling and root planing on gingival crevicular fluid vascular endothelial growth factor level in chronic periodontitis… PMID:27563195 | 2016 | this review only | not stated | not extracted yet |
| Peruzzo Lopes 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pragada 2019 Effect of scaling and root planing on gingival crevicular fluid levels of adrenomedullin in chronic periodontitis patients with and… PMID:31070151 | 2019 | this review only | not stated | not extracted yet |
| Sonoki 2006 Decreased lipid peroxidation following periodontal therapy in type 2 diabetic patients. PMID:17076618 | 2006 | this review only | not stated | not extracted yet |
| Sundaram 2017 Evaluation of Micronutrient (Zinc, Magnesium, and Copper) Levels in Serum and Glycemic Status after Nonsurgical Periodontal Therapy in… PMID:28566847 | 2017 | this review only | not stated | not extracted yet |
| Tervonen 1991 Immediate response to nonsurgical periodontal treatment in subjects with diabetes mellitus. PMID:2045520 | 1991 | this review only | not stated | not extracted yet |
| Tervonen 1997 Periodontal disease related to diabetic status. A pilot study of the response to periodontal therapy in type 1 diabetes. PMID:9226392 | 1997 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (18 years or older) with mild to severe periodontitis, with and without diabetes mellitus, receiving non-surgical periodontal therapy | 1425 participants (792 with DM) in 30 unique studies (n=30); 28 studies in meta-analysis |
| Intervention | Exposure: diabetes mellitus (type I, type II or unspecified), self-reported or clinically assessed | DM (26 studies type II, 3 type I, 2 unspecified/mixed) |
| Comparison | Periodontitis patients without DM | Non-diabetic periodontitis patients |
| Outcomes | PPD and CAL (primary); gingival indices, plaque indices and gingival recession (secondary) | PPD, CAL, BOP, GBI, gingival index, plaque score, plaque index, recession (baseline, post-NSPT, incremental) |
| Study designs | Any prospective or observational study with at least two groups (DM and non-DM) | 30 controlled observational studies (some originally RCTs) |
| Timing | Change over time; longest follow-up within 1 year | Follow-up 1 to 12 months; mostly 3 to 4 months |