Non-Cochrane · aetiology · PM42422780
CBCT analysis of pharyngeal airway dimensions in cleft lip and palate: A systematic review and meta-analysis.
Rai Shalu, Debnath Puja, Deb Barma Manali, et al. · National journal of maxillofacial surgery · 2026 · PubMed · doi:10.4103/njms.njms_9_25
Findings
Population Individuals with unilateral cleft lip and palate (UCLP), children and adults
2 findings
| UCLP (cleft exposure) assessed by CBCT | Noncleft controls | Total pharyngeal airway volume CBCT airway segmentation; age-matched or adjusted controls | SMD -0.97 [-1.32, -0.61] GRADE not reported 5 studies · 255 participants |
| UCLP (cleft exposure) assessed by CBCT | Noncleft controls | Nasopharyngeal airway volume CBCT airway segmentation; age-matched or adjusted controls | SMD -0.29 [-1.16, 0.59] GRADE not reported 3 studies · 126 participants |
Included primary studies 49
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Abdelkarim 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Abdelkarim AZ 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Al-Fahdawi 2017 Cone-Beam Computed Tomography Analysis of the Nasopharyngeal Airway in Nonsyndromic Cleft Lip and Palate Subjects. PMID:26752132 | 2017 | this review only | Nasopharyngeal airway volume | not extracted yet |
| Al-Fahdawi 2018 Cone Beam Computed Tomography Analysis of Oropharyngeal Airway in Preadolescent Nonsyndromic Bilateral and Unilateral Cleft Lip and Palate… PMID:27427930 | 2018 | this review only | not stated | not extracted yet |
| Al-Fahdawi MA 2017 matched by author and year (probable) | NR | this review only | Nasopharyngeal airway volume | not extracted yet |
| Al-Fahdawi MA 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Al-Hout 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Al-Hout G 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Celikoglu 2014 (BCLP) Assessment of pharyngeal airway volume in adolescent patients affected by bilateral cleft lip and palate using cone beam computed… PMID:24665888 | 2014 | this review only | not stated | not extracted yet |
| Celikoglu 2014 (UCLP) Three-dimensional evaluation of the pharyngeal airway volumes in patients affected by unilateral cleft lip and palate. PMID:24880849 | 2014 | this review only | Total pharyngeal airway volume | not extracted yet |
| Celikoglu M 2014a matched by author and year (probable) | NR | this review only | Total pharyngeal airway volume | not extracted yet |
| Chen 2022 The study on the morphological changes of oropharynx in patients with complete unilateral cleft lip and palate after palatopharyngeal… PMID:36248646 | 2022 | this review only | not stated | not extracted yet |
| Chen B 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Cheung 2012 Three dimensional assessment of the pharyngeal airway in individuals with non-syndromic cleft lip and palate. PMID:22952677 | 2012 | this review only | not stated | not extracted yet |
| Cheung T, Oberoi S 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Diwakar 2015 Three-dimensional evaluation of pharyngeal airway in complete unilateral cleft individuals and normally growing individuals using cone… PMID:25007033 | 2015 | this review only | Nasopharyngeal airway volume | not extracted yet |
| Diwakar R 2015 matched by author and year (probable) | NR | this review only | Nasopharyngeal airway volume | not extracted yet |
| Ertas 2019 Evaluation of Nasal Airway Volume of Operated Unilateral Cleft Lip and Palate Patients Compared With Skeletal Class III Individuals. PMID:29738291 | 2019 | this review only | Nasopharyngeal airway volume | not extracted yet |
| Ertas U 2019 matched by author and year (probable) | NR | this review only | Nasopharyngeal airway volume | not extracted yet |
| Eslami 2023 Comparison of Nasopharyngeal Airway Volume in Cleft Lip and Palate Patients With Normal Individuals Using Cone Beam Computed Tomography. PMID:36210490 | 2023 | this review only | not stated | not extracted yet |
| Eslami N 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gandedkar 2017 Comparative Evaluation of the Pharyngeal Airway Space in Unilateral and Bilateral Cleft Lip and Palate Individuals With Noncleft… PMID:27441696 | 2017 | this review only | Total pharyngeal airway volume | not extracted yet |
| Gandedkar NH 2017 matched by author and year (probable) | NR | this review only | Total pharyngeal airway volume | not extracted yet |
| Karia 2017 Three-dimensional evaluation of the airway spaces in patients with and without cleft lip and palate: A digital volume tomographic study. PMID:28863918 | 2017 | this review only | not stated | not extracted yet |
| Karia H 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kiaee 2021 Three-dimensional assessment of airway volumes in patients with unilateral cleft lip and palate. PMID:34746995 | 2021 | this review only | Total pharyngeal airway volume | not extracted yet |
| Kiaee B 2021 matched by author and year (probable) | NR | this review only | Total pharyngeal airway volume | not extracted yet |
| Kuang 2021 Three-Dimensional Analysis of the Pharyngeal Airway Volume and Craniofacial Morphology in Patients With Bilateral Cleft Lip and Palate. PMID:32812438 | 2021 | this review only | not stated | not extracted yet |
| Kuang W 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nemtoi 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nemtoi A 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pimenta 2014 Three-dimensional evaluation of nasopharyngeal airways of unilateral cleft lip and palate patients. PMID:25180659 | 2015 | this review only | not stated | not extracted yet |
| Pimenta LA 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Shahidi 2016 Comparison of the Pharyngeal Airway Volume between Non-Syndromic Unilateral Cleft Palate and Normal Individuals Using Cone Beam Computed… PMID:27840840 | 2016 | this review only | not stated | not extracted yet |
| Shahidi S 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Takahashi 2020 Three-dimensional assessment of the pharyngeal airway in Japanese preschoolers with orofacial clefts. PMID:30977521 | 2020 | this review only | not stated | not extracted yet |
| Takahashi M 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Trindade-Suedam 2017 Tomographic Pharyngeal Dimensions in Individuals With Unilateral Cleft Lip/Palate and Class III Malocclusion Are Reduced When Compared… PMID:27148639 | 2017 | this review only | not stated | not extracted yet |
| Trindade-Suedam IK 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wiwattanadittakul 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wiwattanadittakul 2024 Comparative evaluation of the upper pharyngeal airway among children with/without UCLP and with/without OSA. PMID:39614951 | 2024 | this review only | not stated | not extracted yet |
| Wiwattanadittakul P 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wiwattanadittakul P 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Xu 2013 3-dimensional computed tomographic analysis of the pharynx in adult patients with unrepaired isolated cleft palate. PMID:23541993 | 2013 | this review only | not stated | not extracted yet |
| Xu 2020 Three-Dimensional Computed Tomography Analysis of Pharynx in Juvenile Patients With Unrepaired Isolated Cleft Palate. PMID:32150799 | 2020 | this review only | Total pharyngeal airway volume | not extracted yet |
| Yoshihara 2012 Three-dimensional analysis of the pharyngeal airway morphology in growing Japanese girls with and without cleft lip and palate. PMID:22449605 | 2012 | this review only | not stated | not extracted yet |
| Yoshihara M 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zhang 2020 Cone-Beam Computed Tomography Evaluation of Skeletal Deformities and Pharyngeal Airway in Chinese Han Individuals With Nonsyndromic… PMID:31296040 | 2020 | this review only | Total pharyngeal airway volume | not extracted yet |
| Zhang Y 2020 matched by author and year (probable) | NR | this review only | Total pharyngeal airway volume | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Children and adults with unilateral/bilateral cleft lip and palate | Nonsyndromic CLP patients (mainly UCLP; some BCLP and isolated cleft palate), children to adults (n=26 studies) |
| Intervention | Airway data assessed by CBCT | CBCT airway assessment (total, nasopharyngeal, oropharyngeal, hypopharyngeal volume) |
| Comparison | Untreated subjects/controls (noncleft) | Age- and sex-matched noncleft controls |
| Outcomes | Morphometric and volumetric airway changes in the upper, middle and lower pharyngeal airway | Total pharyngeal airway volume; nasopharyngeal airway volume; oropharyngeal airway volume |
| Study designs | RCTs, cohort, case-control or cross-sectional studies, 2012 to 2025, English, human | Case-control studies (n=26), published 2012 to 2024 |
| Timing | Not specified | Not specified |