Non-Cochrane · aetiology · PM42074956
Periodontitis and Pancreatic Cancer Risk: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.
Segura Cueva Kareelend Andreina, Velásquez Andrea Bermúdez, Guim Martínez Carlos Andrés, et al. · Journal of clinical medicine · 2026 · PubMed · doi:10.3390/jcm15083154
Findings
Population Adults from the general population or healthcare patients with periodontal status assessed
4 findings
| Periodontitis (clinical, radiographic, self-reported, registry diagnosis or tooth loss attributable to periodontal disease) | No periodontitis or healthy/mild periodontal status | Pancreatic cancer incidence or risk Community and healthcare populations · Region: Europe | logHR 0.44 [-0.18, 1.06] GRADE not reported 2 studies |
| Periodontitis (clinical, radiographic, self-reported, registry diagnosis or tooth loss attributable to periodontal disease) | No periodontitis or healthy/mild periodontal status | Pancreatic cancer incidence or risk Community and healthcare populations · Overall | HR 1.56 [1.28, 1.89] Very low Downgraded: inconsistency, indirectness 8 studies · 476245 participants |
| Periodontitis (clinical, radiographic, self-reported, registry diagnosis or tooth loss attributable to periodontal disease) | No periodontitis or healthy/mild periodontal status | Pancreatic cancer incidence or risk Community and healthcare populations · Region: Asia | logHR 0.45 [0.20, 0.71] GRADE not reported 2 studies |
| Periodontitis (clinical, radiographic, self-reported, registry diagnosis or tooth loss attributable to periodontal disease) | No periodontitis or healthy/mild periodontal status | Pancreatic cancer incidence or risk Community and healthcare populations · Region: USA | logHR 0.53 [0.29, 0.76] GRADE not reported 4 studies |
Included primary studies 8
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Chang 2016 Investigating the Association Between Periodontal Disease and Risk of Pancreatic Cancer. PMID:26474422 | 2016 | this review only | Pancreatic cancer incidence or risk | not extracted yet |
| Fan 2018 Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. PMID:27742762 | 2018 | this review only | Pancreatic cancer incidence or risk | not extracted yet |
| Gerlovin 2019 Oral Health in Relation to Pancreatic Cancer Risk in African American Women. PMID:30923045 | 2019 | this review only | Pancreatic cancer incidence or risk | not extracted yet |
| Heikkila 2018 Periodontitis and cancer mortality: Register-based cohort study of 68,273 adults in 10-year follow-up. PMID:29322513 | 2018 | this review only | Pancreatic cancer incidence or risk | not extracted yet |
| Michaud 2007 A prospective study of periodontal disease and pancreatic cancer in US male health professionals. PMID:17228001 | 2007 | this review only | Pancreatic cancer incidence or risk | not extracted yet |
| Michaud 2013 Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. PMID:22990306 | 2013 | this review only | Pancreatic cancer incidence or risk | not extracted yet |
| Stolzenberg-Solomon 2003 Tooth loss, pancreatic cancer, and Helicobacter pylori. PMID:12816788 | 2003 | this review only | Pancreatic cancer incidence or risk | not extracted yet |
| Yu 2022 Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009-2016. PMID:36273086 | 2022 | this review only | Pancreatic cancer incidence or risk | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (>=18 years) from the general population or receiving healthcare, with documented periodontal assessment | Adults (n=476,245 across 8 studies) from USA, Taiwan, China, UK and Finland |
| Intervention | Exposure: periodontitis diagnosed clinically (PD, CAL, BOP), radiographically, by CDC/AAP criteria, or tooth loss attributable to periodontal disease | Periodontitis (clinical, ICD-coded, self-reported, tooth loss, oral microbiome or antibody markers) (n=8 studies) |
| Comparison | Individuals without periodontitis or with healthy/mild periodontal status | No periodontitis/healthy or mild periodontal status |
| Outcomes | Incidence or risk of developing pancreatic cancer (RR, HR, OR) | Pancreatic cancer incidence (pooled HR 1.56, 95% CI 1.28-1.89) |
| Study designs | Observational studies (cohort, nested case-control, cross-sectional with risk estimates) | Prospective cohort, retrospective cohort, nationwide cohort, nested case-control (n=8) |
| Timing | Not specified | Not specified |