Non-Cochrane · aetiology · PM42027398
Periodontal Disease and Risk of Heart Failure: A Systematic Review and Meta-Analysis.
Valenzuela-Rodríguez German, Diaz-Arocutipa Carlos, Mayta-Tovalino Frank, et al. · International journal of dentistry · 2026 · PubMed · doi:10.1155/ijod/3288710
Findings
Population Adults (cohort studies)
4 findings
| Periodontal disease or periodontitis | No periodontal disease or periodontitis | Heart failure (incidence, as defined by each study) Follow-up 5.4 to 13 years · All seven cohort studies (primary analysis) | RR 1.58 [1.2, 2.07] GRADE not reported 7 studies · 376166 participants |
| Periodontal disease or periodontitis | No periodontal disease or periodontitis | Heart failure (incidence, as defined by each study) Follow-up 5.4 to 13 years · Sensitivity analysis: four studies with similar populations and outcomes (Molinsky, Walther, Yan, Chang) | RR 1.73 [1.13, 2.67] GRADE not reported 4 studies · 186337 participants |
| Periodontal disease (excluding studies that defined periodontitis) | No periodontal disease or periodontitis | Heart failure (incidence, as defined by each study) Follow-up 5.4 to 13 years · Sensitivity analysis: excluding studies that used periodontitis (Huh, Molinsky, Nabila, Chang) | RR 1.3 [1.02, 1.66] GRADE not reported 4 studies · 355168 participants |
| Periodontitis | No periodontal disease or periodontitis | Heart failure (incidence, as defined by each study) Follow-up 5.4 to 13 years · Studies assessing periodontitis (Norhammar, Walther, Yan) | RR 2.26 [1.58, 3.23] GRADE not reported 3 studies · 20998 participants |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Chang 2020 Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: A nationwide… PMID:31786965 | 2020 | this review only | Heart failure (incidence, as defined by each study) | not extracted yet |
| Huh 2023 Association of Dental Diseases and Oral Hygiene Care With the Risk of Heart Failure in Patients With Type 2 Diabetes: A Nationwide Cohort… PMID:37548156 | 2023 | this review only | Heart failure (incidence, as defined by each study) | not extracted yet |
| Molinsky 2022 Periodontal Status, C-Reactive Protein, NT-proBNP, and Incident Heart Failure: The ARIC Study. PMID:36175058 | 2022 | this review only | Heart failure (incidence, as defined by each study) | not extracted yet |
| Nabila 2023 Bidirectional associations between periodontal disease and systemic diseases: a nationwide population-based study in Korea. PMID:37640779 | 2023 | this review only | Heart failure (incidence, as defined by each study) | not extracted yet |
| Norhammar 2024 Does Periodontitis Increase the Risk for Future Cardiovascular Events? Long-Term Follow-Up of the PAROKRANK Study. PMID:39261983 | 2025 | this review only | Heart failure (incidence, as defined by each study) | not extracted yet |
| Walther 2022 Association between periodontitis and heart failure in the general population. PMID:36101477 | 2022 | this review only | Heart failure (incidence, as defined by each study) | not extracted yet |
| Yan 2022 Periodontitis Is Associated With Heart Failure: A Population-Based Study (NHANES III). PMID:35514329 | 2022 | this review only | Heart failure (incidence, as defined by each study) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults; cohort or case-control studies reporting periodontal disease or periodontitis and heart failure; no exclusion by comorbidity | Adults in seven cohort studies (n=376,166), mean age 43-65.3 years |
| Intervention | Periodontal disease or periodontitis (exposure) | Periodontal disease or periodontitis (n=7 studies) |
| Comparison | No periodontal disease or periodontitis | No periodontal disease or periodontitis |
| Outcomes | Heart failure as defined by each study | Heart failure (n=7 studies) |
| Study designs | Cohort or case-control studies; case reports and case series excluded | Seven cohort studies (5 prospective, 2 retrospective) |
| Timing | No exclusion based on follow-up period | Follow-up 5.4-13 years |