Non-Cochrane · intervention · PM41590800
Clinical and Radiographic Outcomes of Vital Pulp Therapy Using Resin-Modified Versus Conventional Calcium Silicate-Based Materials: A Systematic Review and Meta-Analysis.
Cabrera-Fernández Alberto, Dominguez-Dominguez Laura, Pérez-Pérez Antonio, et al. · Journal of functional biomaterials · 2026 · PubMed · doi:10.3390/jfb17010032
Findings
11 findings
| Population | ||||
|---|---|---|---|---|
| Vital pulp therapy (IPC, DPC or pulpotomy) in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Non-resin-modified calcium silicate materials (Biodentine, MTA, iRoot BP Plus, CEM) | Combined clinical and radiographic success 180 days | RR 0.97 [0.9, 1.04] -28 [-93, 37] per 1000 Low Downgraded: risk of bias, imprecision 4 studies · 281 participants |
| Vital pulp therapy (IPC, DPC or pulpotomy) in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Non-resin-modified calcium silicate materials (Biodentine, MTA, iRoot BP Plus, CEM) | Combined clinical and radiographic success 360 days | RR 0.89 [0.69, 1.13] -99 [-279, 117] per 1000 Low Downgraded: risk of bias, imprecision 4 studies · 237 participants |
| Vital pulp therapy (IPC, DPC or pulpotomy) in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Non-resin-modified calcium silicate materials (Biodentine, MTA, iRoot BP Plus, CEM) | Dentine bridge formation 360 days · Direct pulp capping and pulpotomy | RR 0.85 [0.76, 0.95] -119 [-190, -40] per 1000 Low Downgraded: risk of bias, imprecision 3 studies · 451 participants |
| Vital pulp therapy (IPC, DPC or pulpotomy) in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Non-resin-modified calcium silicate materials (Biodentine, MTA, iRoot BP Plus, CEM) | Combined clinical and radiographic success 90 days | RR 1.01 [0.96, 1.07] 10 [-38, 67] per 1000 Low Downgraded: risk of bias, imprecision 3 studies · 232 participants |
| Direct pulp capping in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Non-resin-modified calcium silicate materials | Combined clinical and radiographic success 180 days · Direct pulp capping only | RR 0.99 [0.88, 1.11] -9 [-108, 99] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 149 participants |
| Direct pulp capping in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Non-resin-modified calcium silicate materials | Dentine bridge formation 180 days · Direct pulp capping only | RR 0.99 [0.9, 1.08] -8 [-83, 67] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 388 participants |
| Direct pulp capping in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Non-resin-modified calcium silicate materials | Combined clinical and radiographic success 90 days · Direct pulp capping only | RR 1.05 [0.98, 1.14] 47 [-19, 131] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 122 participants |
| Direct pulp capping in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Non-resin-modified calcium silicate materials | Combined clinical and radiographic success 360 days · Direct pulp capping only | RR 0.9 [0.76, 1.08] -89 [-214, 71] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 111 participants |
| Direct pulp capping in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Biodentine | Combined clinical and radiographic success 180 days · Subgroup: TheraCal LC vs Biodentine | RR 0.99 [0.86, 1.14] -9 [-126, 126] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 98 participants |
| Direct pulp capping in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Biodentine | Combined clinical and radiographic success 90 days · Subgroup: TheraCal LC vs Biodentine | RR 1.04 [0.95, 1.14] 38 [-48, 133] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 82 participants |
| Direct pulp capping in permanent teeth with deep caries and a vital pulp requiring vital pulp therapy | Resin-modified calcium silicate material (TheraCal LC) | Biodentine | Combined clinical and radiographic success 360 days · Subgroup: TheraCal LC vs Biodentine | RR 0.86 [0.71, 1.03] -132 [-274, 28] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 72 participants |
Included primary studies 14
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Peskersoy 2021 Efficacy of different calcium silicate materials as pulp-capping agents: Randomized clinical trial. PMID:33854725 | 2021 | 2 other reviews | not stated | not extracted yet |
| Awadhesh 2025 Comparative evaluation of four different calcium-based medicaments as an indirect pulp capping agent: An in vivo study. PMID:41169767 | 2025 | 1 other review | not stated | not extracted yet |
| Gurcan 2019 DOI:10.23804/ejpd.2019.20.02.04 | NR | 1 other review | not stated | not extracted yet |
| Gurcan 2019 Clinical and radiographic evaluation of indirect pulp capping with three different materials: a 2-year follow-up study. PMID:31246084 | 2019 | 1 other review | not stated | not extracted yet |
| Iyer 2021 Comparative evaluation of different direct pulp capping agents in carious tooth: An in vivo study. PMID:35035155 | 2021 | 1 other review | not stated | not extracted yet |
| Velioglu 2021 Dört Direkt Pulpa Kapaklama Materyalinin Klinik Takibinin Değerlendirilmesi: Bir Klinik Çalışma DOI:10.15311/selcukdentj.829044 | 2021 | 1 other review | not stated | not extracted yet |
| Baranwal 2024 Comparative evaluation of dual-cure resin (TheraCal PT) and Biodentine in coronal pulpotomy of patients with symptoms indicative of… PMID:39372577 | 2024 | this review only | not stated | not extracted yet |
| Mahapatra 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mahapatra 2024 Comparative Evaluation of the Efficacy of TheraCal LC, Mineral Trioxide Aggregate, and Biodentine As Direct Pulp Capping Materials in… PMID:38558621 | 2024 | this review only | not stated | not extracted yet |
| Nagi 2024 Effectiveness of TheraCal LC versus MTA in Vital Pulp Therapy of Cariously-Exposed Young Permanent Molars: Five-Year Follow up of a… DOI:10.21608/adjalexu.2024.260039.1459 | 2024 | this review only | not stated | not extracted yet |
| Nagi 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Velioglu 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zhang 2024 Clinical influencing factors of vital pulp therapy on pulpitis permanent teeth with 2 calcium silicate-based materials: A randomized… DOI:10.1097/md.0000000000038015 | 2024 | this review only | not stated | not extracted yet |
| Zhang 2024 Clinical influencing factors of vital pulp therapy on pulpitis permanent teeth with 2 calcium silicate-based materials: A randomized… PMID:38701294 | 2024 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Permanent teeth with deep carious lesions and vital pulp (reversible or symptomatic irreversible pulpitis) treated with vital pulp therapy | Permanent teeth with reversible pulpitis (one trial also irreversible pulpitis); 22 to 525 teeth per trial (n=9 trials) |
| Intervention | Resin-modified calcium silicate-based materials (TheraCal LC, TheraCal PT) | TheraCal LC (8 trials); TheraCal PT (1 trial) |
| Comparison | Conventional resin-free calcium silicate-based materials (Biodentine, ProRoot MTA, NeoMTA, iRoot BP Plus, CEM) | Biodentine (5), ProRoot MTA (3), MTA Plus (2), MTA Angelus (1), CEM Cement (1), iRoot BP Plus (1) |
| Outcomes | Combined clinical and radiographic success at 3-36 months; dentine bridge formation | Combined clinical and radiographic success; dentine bridge formation |
| Study designs | Randomised clinical trials (parallel or split-mouth) | 9 RCTs |
| Timing | 3 to 36 months follow-up | 90, 180 and 360 days |