Non-Cochrane · intervention · PM41893203
Resin-Modified Calcium Silicate-Based Materials Versus Conventional Formulations in Primary Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Outcomes of Vital Pulp Therapy Procedures in Pediatric Dentistry.
Cabrera-Fernández Alberto, Dominguez-Dominguez Laura, Pérez-Pérez Antonio, et al. · Journal of functional biomaterials · 2026 · PubMed · doi:10.3390/jfb17030147
Findings
6 findings
| Population | ||||
|---|---|---|---|---|
| Primary teeth with deep caries and vital pulp (healthy pulp or reversible pulpitis) | TheraCal LC (resin-modified calcium silicate) in vital pulp therapy (ipc, dpc, pulpotomy) | Non-resin calcium silicate materials (MTA ProRoot, MTA Angelus, Biodentine) | Overall clinical and radiographic success <360 days | RR 0.99 [0.96, 1.02] -10 [-40, 20] per 1000 Low Downgraded: risk of bias, imprecision 7 studies · 400 participants |
| Primary teeth with deep caries and vital pulp (healthy pulp or reversible pulpitis) | TheraCal LC (resin-modified calcium silicate) in vital pulp therapy (ipc, dpc, pulpotomy) | Non-resin calcium silicate materials (MTA ProRoot, MTA Angelus, Biodentine) | Overall clinical and radiographic success >=360 days | RR 0.95 [0.89, 1.01] -46 [-101, 9] per 1000 Low Downgraded: risk of bias, imprecision 5 studies · 355 participants |
| Primary teeth with deep caries and vital pulp (healthy pulp or reversible pulpitis) | TheraCal LC (resin-modified calcium silicate) for indirect pulp capping | Non-resin calcium silicate materials (MTA ProRoot, MTA Angelus, Biodentine) | Overall clinical and radiographic success <360 days · Procedure: Indirect pulp capping | RR 0.99 [0.95, 1.03] -10 [-50, 30] per 1000 Low Downgraded: risk of bias, imprecision 5 studies · 218 participants |
| Primary teeth with deep caries and vital pulp (healthy pulp or reversible pulpitis) | TheraCal LC (resin-modified calcium silicate) for indirect pulp capping | Non-resin calcium silicate materials (MTA ProRoot, MTA Angelus, Biodentine) | Overall clinical and radiographic success >=360 days · Procedure: Indirect pulp capping | RR 0.94 [0.86, 1.03] -57 [-132, 28] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 153 participants |
| Primary teeth with deep caries and vital pulp (healthy pulp or reversible pulpitis) | TheraCal LC (resin-modified calcium silicate) for pulpotomy | Non-resin calcium silicate materials (MTA ProRoot, MTA Angelus, Biodentine) | Overall clinical and radiographic success >=360 days · Procedure: Pulpotomy | RR 0.95 [0.85, 1.06] -43 [-128, 51] per 1000 Low Downgraded: risk of bias, imprecision 2 studies · 124 participants |
| Primary teeth with deep caries and vital pulp (healthy pulp or reversible pulpitis) requiring vital pulp therapy | Other resin-modified calcium silicate materials (TheraCal PT, BioCal-CAP, Oxford ActiveCal CP) | Non-resin calcium silicate materials (MTA ProRoot, MTA Angelus, Biodentine) | Combined clinical and radiographic success | no estimate extracted No studies found 0 studies |
Included primary studies 9
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Gurcan 2019 Clinical and radiographic evaluation of indirect pulp capping with three different materials: a 2-year follow-up study. PMID:31246084 | 2019 | 1 other review | Overall clinical and radiographic success | not extracted yet |
| Abdelhafez 2022 matched by author and year (probable) | NR | this review only | Overall clinical and radiographic success | not extracted yet |
| ElHameed 2025 Clinical and radiographic evaluation of indirect pulp capping using biodentine and theracal LC in primary molars DOI:10.4103/tdj.tdj_46_24 | 2024 | this review only | Overall clinical and radiographic success | not extracted yet |
| Erfanparast 2018 Direct pulp capping in primary molars using a resin-modified Portland cement-based material (TheraCal) compared to MTA with 12-month… PMID:29767382 | 2018 | this review only | Overall clinical and radiographic success | not extracted yet |
| Hassanpour 2023 Comparison between the Radiographic and Clinical Rates of Success for TheraCal and MTA in Primary Tooth Pulpotomy within a 12-Month… PMID:37124935 | 2023 | this review only | Overall clinical and radiographic success | not extracted yet |
| Menon 2016 Clinical and radiographic comparison of indirect pulp treatment using light-cured calcium silicate and mineral trioxide aggregate in… PMID:27994414 | 2016 | this review only | Overall clinical and radiographic success | not extracted yet |
| Sahin 2021 Clinical, radiographic, and histological evaluation of three different pulp-capping materials in indirect pulp treatment of primary teeth:… PMID:33404764 | 2021 | this review only | Overall clinical and radiographic success | not extracted yet |
| Saikia 2023 Evaluation of Indirect Pulp Capping Using MTA, Light-cured Calcium Silicate, and Propolis in Primary Teeth: A Clinical and Radiographic… PMID:38162240 | 2023 | this review only | Overall clinical and radiographic success | not extracted yet |
| Thomas 2024 Comparative Evaluation of Effectiveness of Calcium Hydroxide, MTA, and TheraCal LC in Indirect Pulp Capping in Primary Molars: In Vivo… PMID:38956853 | 2024 | this review only | Overall clinical and radiographic success | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Clinical and Radiographic Outcomes of Vital Pulp Therapy Using Resin-Modified Versus Conventional Calcium Silicate-Based Materials: A… (2026) | 1 | 0.05 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Primary teeth with deep carious lesions and vital pulp (healthy pulp or reversible pulpitis) treated by vital pulp therapy | Primary teeth with reversible pulpitis or normal pulp, aged 3 to 15 years (n=40 to 295 teeth per trial) |
| Intervention | Resin-modified calcium silicate-based materials (e.g., TheraCal LC, TheraCal PT, BioCal-CAP) in vital pulp therapy | TheraCal LC only (n=9 trials); IPC, DPC and pulpotomy |
| Comparison | Conventional resin-free calcium silicate-based materials (Biodentine, ProRoot MTA, MTA Angelus) | MTA ProRoot (n=4), MTA Angelus (n=3), Biodentine (n=2) |
| Outcomes | Primary: overall clinical and radiographic success at 3 to 36 months; secondary: increase in dentin thickness | Combined clinical and radiographic success (meta-analyzed); dentin thickness (4 trials, narrative only) |
| Study designs | Randomized clinical trials (parallel-group or split-mouth) | Randomized clinical trials (n=9) |
| Timing | Follow-up 3 to 36 months | Follow-up 90 to 720 days |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Yes | Partial Yes | no |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Yes | Partial Yes | no |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | NRSI: N/A · RCT: Yes | RCT: Yes · NRSI: N/A | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | RCT: Yes · NRSI: N/A | yes |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |