Non-Cochrane · intervention · PM41440325
The Effect of Adjunctive Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implant Diseases: Systematic Review and Meta-Analysis.
Nastri Livia, Annunziata Marco, Mariani Pierluigi, et al. · Dentistry journal · 2025 · PubMed · doi:10.3390/dj13120567
Findings
5 findings
| Population | ||||
|---|---|---|---|---|
| Patients with peri-implant mucositis or peri-implantitis | Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) | Mechanical debridement alone | Marginal bone level change (MBLc), mm 6-month follow-up · Non-surgical treatment of peri-implant disease · Abstract-reported value (differs from Figure 3a) | MD 0.29 [0.12, 0.46] GRADE not reported 4 studies |
| Patients with peri-implant mucositis or peri-implantitis (non-surgical treatment) | Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) | Mechanical debridement alone | Bleeding on probing (BOP) change, % 6 months · Abstract-reported estimate | MD 5.59 [1.19, 9.86] GRADE not reported 5 studies |
| Patients with peri-implant mucositis or peri-implantitis | Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) | Mechanical debridement alone | Marginal bone level change (MBLc), mm 6-month follow-up · Non-surgical treatment of peri-implant disease | MD 0.34 [0.10, 0.57] GRADE not reported 4 studies · 253 participants |
| Patients with peri-implant mucositis or peri-implantitis | Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) | Mechanical debridement alone | Probing depth (PD) change, mm 6-month follow-up · Non-surgical treatment of peri-implant disease | MD 0.46 [-0.09, 1.02] GRADE not reported 4 studies · 317 participants |
| Patients with peri-implant mucositis or peri-implantitis | Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) | Mechanical debridement alone | Bleeding on probing (BOP) change, % 6-month follow-up · Non-surgical treatment of peri-implant disease | MD 5.52 [1.19, 9.86] GRADE not reported 5 studies · 313 participants |
Included primary studies 11
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ahmed 2020 The effectiveness of photodynamic and antibiotic gel therapy as an adjunct to mechanical debridement in the treatment of peri-implantitis… PMID:33157330 | 2020 | 1 other review | Marginal bone level change (MBLc), mm; Probing depth (PD) change, mm; Bleeding on probing (BOP) change, % | not extracted yet |
| Labban 2021 Clinical, bacterial, and inflammatory outcomes of indocyanine green-mediated photodynamic therapy for treating periimplantitis among… PMID:34033934 | 2021 | 1 other review | Marginal bone level change (MBLc), mm; Probing depth (PD) change, mm; Bleeding on probing (BOP) change, % | not extracted yet |
| Abduljabbar 2017 Effect of mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of peri-implant diseases in… PMID:27989865 | 2017 | this review only | Bleeding on probing (BOP) change, % | not extracted yet |
| Al Amri 2016 Efficacy of periimplant mechanical debridement with and without adjunct antimicrobial photodynamic therapy in patients with type 2… PMID:27129871 | 2016 | this review only | Marginal bone level change (MBLc), mm; Bleeding on probing (BOP) change, % | not extracted yet |
| ALHarthi 2022 Effect of multiple sessions of photodynamic therapy on bone regeneration around dental implants among patients with peri‑implantitis. PMID:34740836 | 2022 | this review only | not stated | not extracted yet |
| Alqahtani 2019 Efficacy of mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of peri-implantitis among… PMID:31525451 | 2019 | this review only | Marginal bone level change (MBLc), mm; Probing depth (PD) change, mm; Bleeding on probing (BOP) change, % | not extracted yet |
| Bombeccari 2013 Photodynamic therapy to treat periimplantitis. PMID:24225780 | 2013 | this review only | not stated | not extracted yet |
| Esposito 2013 The adjunctive use of light-activated disinfection (LAD) with FotoSan is ineffective in the treatment of peri-implantitis: 1-year results… PMID:23926583 | 2013 | this review only | not stated | not extracted yet |
| Javed 2016 Efficacy of periimplant mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of periimplant… PMID:27600789 | 2016 | this review only | not stated | not extracted yet |
| Romeo 2016 The Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implantitis. PMID:27429618 | 2016 | this review only | not stated | not extracted yet |
| Wang 2019 Adjunctive photodynamic therapy improves the outcomes of peri-implantitis: a randomized controlled trial. PMID:31152567 | 2019 | this review only | Probing depth (PD) change, mm | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with peri-implant disease (mucositis or peri-implantitis) with defined diagnostic criteria and 10 or more patients | Patients with peri-implant diseases, many with type 2 diabetes, prediabetes or smoking (878 patients, 1056 implants) |
| Intervention | Mechanical debridement plus aPDT (any photosensitizer, any light and wavelength) | Mechanical debridement plus aPDT (diode light 630 to 810 nm; phenothiazine chloride, methylene blue, toluidine blue or ICG) |
| Comparison | Mechanical debridement alone (with or without flap elevation) | Mechanical debridement alone |
| Outcomes | Marginal bone level change (primary); probing depth and bleeding on probing changes (secondary) | MBL change, PD change and BOP change at 6 months (and 12 months in one study) |
| Study designs | RCTs in English | 11 RCTs (n=11); 4 to 5 included in each meta-analysis |
| Timing | Minimum follow-up 6 months | 6 months in most studies; 9 months (n=1) and 12 months (n=3) |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | No | No | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | No | no |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | Yes | Yes | yes |
| 8Included studies described in detail | Yes | Partial Yes | no |
| 9Risk of bias assessed satisfactorilycritical | NRSI: N/A · RCT: Yes | RCT: Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | NRSI: N/A · RCT: Yes | RCT: No | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | No | No | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |