evidencegaps
Primary study · included by 2 reviews

Clinical, bacterial, and inflammatory outcomes of indocyanine green-mediated photodynamic therapy for treating periimplantitis among diabetic patients: A randomized controlled clinical trial.

Labban 2021 · Labban Nawaf, Shibani Nouf Al, Al-Kattan Reem, et al. · Photodiagnosis and photodynamic therapy · 2021

Included by

The Effect of Adjunctive Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implant Diseases: Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2025 · cited as Labban 2021 · Figure 3; Table 1
Outcome this study informsPooled effectEvidenceCertainty
Marginal bone level change (MBLc), mm
Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) vs Mechanical debridement alone · 6-month follow-up
MD 0.29 [0.12, 0.46]4 studiesGRADE not reported
Bleeding on probing (BOP) change, %
Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) vs Mechanical debridement alone · 6 months
MD 5.59 [1.19, 9.86]5 studiesGRADE not reported
Marginal bone level change (MBLc), mm
Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) vs Mechanical debridement alone · 6-month follow-up
MD 0.34 [0.10, 0.57]4 studies · 253 participantsGRADE not reported
Probing depth (PD) change, mm
Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) vs Mechanical debridement alone · 6-month follow-up
MD 0.46 [-0.09, 1.02]4 studies · 317 participantsGRADE not reported
Bleeding on probing (BOP) change, %
Mechanical debridement plus adjunctive antimicrobial photodynamic therapy (aPDT) vs Mechanical debridement alone · 6-month follow-up
MD 5.52 [1.19, 9.86]5 studies · 313 participantsGRADE not reported
Microbiological Effects of Laser-Assisted Non-Surgical Treatment of Peri-Implantitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Non-Cochrane · intervention · 2026 · cited as Labban 2021 · Table 1; Reference list; Figures 3-5
Outcome this study informsPooled effectEvidenceCertainty
Porphyromonas gingivalis counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · All timepoints combined (baseline, 3 and 6 months)
SMD -0.152 [-0.636, 0.332]3 studies · 189 participantsGRADE not reported
Treponema denticola counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · 6 months
SMD -1.384 [-1.968, -0.8]2 studies · 89 participantsGRADE not reported
Treponema denticola counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · 6 months
SMD -1.559 [-4.994, 1.876]2 studies · 89 participantsVery low
Treponema denticola counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · 3 months
SMD -3.196 [-9.237, 2.846]2 studies · 89 participantsGRADE not reported
Treponema denticola counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · Baseline
SMD 0.103 [-0.358, 0.564]2 studies · 89 participantsGRADE not reported
Porphyromonas gingivalis counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · 3 months
SMD -1.034 [-2.863, 0.796]3 studies · 189 participantsGRADE not reported
Porphyromonas gingivalis counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · Baseline
SMD 0.005 [-0.364, 0.375]3 studies · 189 participantsGRADE not reported
Porphyromonas gingivalis counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · All timepoints combined (baseline, 3 and 6 months)
SMD -0.416 [-0.64, -0.192]3 studies · 189 participantsGRADE not reported
Treponema denticola counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · 3 months
SMD -1.645 [-2.328, -0.962]2 studies · 89 participantsGRADE not reported
Porphyromonas gingivalis counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · 6 months
SMD -0.476 [-1.444, 0.492]3 studies · 189 participantsVery low
Porphyromonas gingivalis counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · Baseline
SMD 0.058 [-0.529, 0.646]3 studies · 189 participantsGRADE not reported
Porphyromonas gingivalis counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · 3 months
SMD -0.837 [-1.253, -0.421]3 studies · 189 participantsGRADE not reported
Porphyromonas gingivalis counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · 6 months
SMD -0.512 [-0.894, -0.13]3 studies · 189 participantsGRADE not reported
Treponema denticola counts
Laser-assisted non-surgical treatment (Er:YAG, diode, photodynamic therapy), alone or adjunctive to mechanical debridement vs Conventional non-surgical mechanical debridement without laser · Baseline
SMD 0.085 [-0.445, 0.614]2 studies · 89 participantsGRADE not reported

2 including reviews in total.