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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

1,558 questions in 115 reviews · Vascular

current versions
No studies 346 · 22.2%Ungraded 90 · 5.8%Very low 281 · 18%Low 477 · 30.6%Moderate 313 · 20.1%High 51 · 3.3%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
Time to hemostasis (seconds) · vascular surgery patients who undergo creation of an anastomosis
The role of sealants for achieving anastomotic hemostasis in vascular surgery (2024) · Cochrane
no estimate extracted7 studies · 498 participantsLow
Intervention NR
Failure of hemostatic intervention ( · vascular surgery patients who undergo creation of an anastomosis
The role of sealants for achieving anastomotic hemostasis in vascular surgery (2024) · Cochrane
RR 0.46 [0.35, 0.61]17 studies · 2120 participantsVery low
Intervention NR
Intraoperative blood loss (mL) · vascular surgery patients who undergo creation of an anastomosis
The role of sealants for achieving anastomotic hemostasis in vascular surgery (2024) · Cochrane
no estimate extracted3 studies · 266 participantsLow
Intervention NR
Operating time (minutes) · vascular surgery patients who undergo creation of an anastomosis
The role of sealants for achieving anastomotic hemostasis in vascular surgery (2024) · Cochrane
no estimate extracted4 studies · 436 participantsLow
Intervention NR
Death from bleeding complications (up to 30 days · vascular surgery patients who undergo creation of an anastomosis
The role of sealants for achieving anastomotic hemostasis in vascular surgery (2024) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Postoperative bleeding (up to 30 days · vascular surgery patients who undergo creation of an anastomosis
The role of sealants for achieving anastomotic hemostasis in vascular surgery (2024) · Cochrane
RR 0.78 [0.59, 1.04]9 studies · 1216 participantsLow
Intervention NR
Unplanned return to the operating room (up to 30 days · vascular surgery patients who undergo creation of an anastomosis
The role of sealants for achieving anastomotic hemostasis in vascular surgery (2024) · Cochrane
RR 0.27 [0.04, 1.69]8 studies · 721 participantsLow
Intervention NR
Change in absolute walking distance from baseline (m) · people with intermittent claudication
Mobile health technologies to improve walking distance in people with intermittent claudication (2024) · Cochrane
no estimate extracted2 studies · 503 participantsLow
Intervention NR
Change in claudication distance from baseline (m) · people with intermittent claudication
Mobile health technologies to improve walking distance in people with intermittent claudication (2024) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Amputation‐free survival · people with intermittent claudication
Mobile health technologies to improve walking distance in people with intermittent claudication (2024) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Revascularisation‐free survival · people with intermittent claudication
Mobile health technologies to improve walking distance in people with intermittent claudication (2024) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Major adverse cardiovascular events (MACE) · people with intermittent claudication
Mobile health technologies to improve walking distance in people with intermittent claudication (2024) · Cochrane
RR 1.37 [0.07, 28.17]1 study · 305 participantsLow
Intervention NR
Major adverse limb events (MALE) · people with intermittent claudication
Mobile health technologies to improve walking distance in people with intermittent claudication (2024) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Above‐ankle amputation · people with intermittent claudication
Mobile health technologies to improve walking distance in people with intermittent claudication (2024) · Cochrane
no estimate extractedNRNo studies
Supervised exercise therapy following vascular intervention vs vascular intervention alone
MWD ‐ change from baseline · people with symptomatic peripheral arterial disease§
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic… (2024) · Cochrane
no estimate extracted2 studies · 89 participantsVery low
Supervised exercise therapy following vascular intervention vs vascular intervention alone
6MWT ‐ change from baseline · people with symptomatic peripheral arterial disease§
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic… (2024) · Cochrane
no estimate extracted1 study · 49 participantsVery low
Supervised exercise therapy following vascular intervention vs vascular intervention alone
PFWD ‐ change from baseline · people with symptomatic peripheral arterial disease§
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic… (2024) · Cochrane
no estimate extracted2 studies · 87 participantsVery low
Supervised exercise therapy following vascular intervention vs vascular intervention alone
ABI ‐ absolute value · people with symptomatic peripheral arterial disease§
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic… (2024) · Cochrane
no estimate extracted2 studies · 110 participantsVery low
Supervised exercise therapy following vascular intervention vs vascular intervention alone
Mortality · people with symptomatic peripheral arterial disease§
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic… (2024) · Cochrane
OR 0.92 [0.42, 2]6 studies · 346 participantsVery low
Supervised exercise therapy following vascular intervention vs vascular intervention alone
Quality of life SF‐36 Physical component absolute score · people with symptomatic peripheral arterial disease§
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic… (2024) · Cochrane
no estimate extracted2 studies · 105 participantsVery low
Supervised exercise therapy following vascular intervention vs vascular intervention alone
Reintervention · people with symptomatic peripheral arterial disease§
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic… (2024) · Cochrane
OR 0.91 [0.23, 3.65]5 studies · 252 participantsVery low
Remote ischaemic preconditioning (RIPC) vs no RIPC
Perioperative mortality (within 1 month after operation) · people undergoing elective major vascular surgery
Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular… (2023) · Cochrane
RR 1.41 [0.59, 3.4]10 studies · 965 participantsModerate
Remote ischaemic preconditioning (RIPC) vs no RIPC
Myocardial infarction (within 1 month after operation) · people undergoing elective major vascular surgery
Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular… (2023) · Cochrane
RR 0.82 [0.49, 1.4]11 studies · 1001 participantsModerate
Remote ischaemic preconditioning (RIPC) vs no RIPC
Renal impairment (within 1 month after operation) · people undergoing elective major vascular surgery
Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular… (2023) · Cochrane
RR 1.07 [0.62, 1.86]12 studies · 1054 participantsModerate
Remote ischaemic preconditioning (RIPC) vs no RIPC
Stroke (within 1 month after operation) · people undergoing elective major vascular surgery
Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular… (2023) · Cochrane
RR 0.33 [0.04, 3.15]4 studies · 392 participantsModerate
Remote ischaemic preconditioning (RIPC) vs no RIPC
Hospital stay · people undergoing elective major vascular surgery
Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular… (2023) · Cochrane
no estimate extracted7 studies · 569 participantsModerate
Remote ischaemic preconditioning (RIPC) vs no RIPC
Limb loss (within 1 month after operation) · people undergoing elective major vascular surgery
Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular… (2023) · Cochrane
RR 0.74 [0.05, 10.61]3 studies · 322 participantsLow
Remote ischaemic preconditioning (RIPC) vs no RIPC
Operating time or total anaesthetic time · people undergoing elective major vascular surgery
Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular… (2023) · Cochrane
no estimate extracted10 studies · 803 participantsModerate
Totally percutaneous vs cut‐down femoral artery access
Short‐term mortality (30‐day or in‐hospital) · people undergoing elective bifurcated abdominal endovascular aneurysm repair
Totally percutaneous versus surgical cut‐down femoral artery access for elective bifurcated abdominal… (2023) · Cochrane
RR 1.5 [0.06, 36.18]2 studies · 181 participantsLow
Totally percutaneous vs cut‐down femoral artery access
Failure of aneurysm exclusion( · people undergoing elective bifurcated abdominal endovascular aneurysm repair
Totally percutaneous versus surgical cut‐down femoral artery access for elective bifurcated abdominal… (2023) · Cochrane
RR 0.17 [0.01, 4.02]1 study · 151 participantsModerate
Totally percutaneous vs cut‐down femoral artery access
Wound infection (30‐day or in‐hospital) · people undergoing elective bifurcated abdominal endovascular aneurysm repair
Totally percutaneous versus surgical cut‐down femoral artery access for elective bifurcated abdominal… (2023) · Cochrane
RR 0.18 [0.01, 3.59]3 studies · 318 participantsModerate
Totally percutaneous vs cut‐down femoral artery access
Major complications (30‐day or in‐hospital) · people undergoing elective bifurcated abdominal endovascular aneurysm repair
Totally percutaneous versus surgical cut‐down femoral artery access for elective bifurcated abdominal… (2023) · Cochrane
RR 1.21 [0.61, 2.41]3 studies · 318 participantsModerate
Totally percutaneous vs cut‐down femoral artery access
Medium‐ to long‐term complications( · people undergoing elective bifurcated abdominal endovascular aneurysm repair
Totally percutaneous versus surgical cut‐down femoral artery access for elective bifurcated abdominal… (2023) · Cochrane
RR 0.82 [0.25, 2.65]1 study · 135 participantsModerate
Totally percutaneous vs cut‐down femoral artery access
Bleeding complications (30‐day or in‐hospital) · people undergoing elective bifurcated abdominal endovascular aneurysm repair
Totally percutaneous versus surgical cut‐down femoral artery access for elective bifurcated abdominal… (2023) · Cochrane
RR 1.02 [0.29, 3.64]2 studies · 181 participantsModerate
Totally percutaneous vs cut‐down femoral artery access
Operating time (minutes) · people undergoing elective bifurcated abdominal endovascular aneurysm repair
Totally percutaneous versus surgical cut‐down femoral artery access for elective bifurcated abdominal… (2023) · Cochrane
no estimate extracted3 studies · 318 participantsLow
Physical exercise vs no treatment
Intensity of disease signs and symptoms: VCSS Scale: 0 to 30 (lower is better) · people with non‐ulcerated chronic venous insufficiency
Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency (2023) · Cochrane
no estimate extracted2 studies · 49 participantsVery low
Physical exercise vs no treatment
Ejection fraction · people with non‐ulcerated chronic venous insufficiency
Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency (2023) · Cochrane
MD 4.881 study · 28 participantsVery low
Physical exercise vs no treatment
Venous refilling time · people with non‐ulcerated chronic venous insufficiency
Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency (2023) · Cochrane
MD 10.73 studies · 72 participantsVery low
Physical exercise vs no treatment
Incidence of venous leg ulcer · people with non‐ulcerated chronic venous insufficiency
Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency (2023) · Cochrane
no estimate extractedNRNo studies
Physical exercise vs no treatment
Quality of life VEINES‐QOL/SF‐36/CIVIQ‐20 (lower is better) · people with non‐ulcerated chronic venous insufficiency
Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency (2023) · Cochrane
MD 4.62 studies · 61 participantsVery low
Physical exercise vs no treatment
Exercise capacity assessed by: time on treadmill (higher is better) · people with non‐ulcerated chronic venous insufficiency
Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency (2023) · Cochrane
MD 77.742 studies · 56 participantsVery low
Physical exercise vs no treatment
Muscle strength assessed by: heel lifts (higher is better) · people with non‐ulcerated chronic venous insufficiency
Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency (2023) · Cochrane
MD 3.13 studies · 89 participantsVery low
Oral DTIs vs conventional anticoagulation
Recurrent VTE (7 months) · participants with diagnosed DVT
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the… (2023) · Cochrane
OR 1.17 [0.83, 1.65]3 studies · 5994 participantsModerate
Oral factor Xa inhibitors vs conventional anticoagulation
Non‐fatal PE (3 to 12 months) · participants with diagnosed DVT
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the… (2023) · Cochrane
OR 0.93 [0.68, 1.27]7 studies · 15166 participantsModerate
Oral factor Xa inhibitors vs conventional anticoagulation
All‐cause mortality (3 to 6 months) · participants with diagnosed DVT
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the… (2023) · Cochrane
OR 0.87 [0.67, 1.14]9 studies · 10770 participantsModerate
Oral factor Xa inhibitors vs conventional anticoagulation
Major bleeding (3 to 12 months) · participants with diagnosed DVT
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the… (2023) · Cochrane
OR 0.63 [0.45, 0.89]17 studies · 18066 participantsHigh
Oral DTIs vs conventional anticoagulation
Recurrent DVT (7 months) · participants with diagnosed DVT
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the… (2023) · Cochrane
OR 1.11 [0.74, 1.66]3 studies · 5994 participantsModerate
Oral DTIs vs conventional anticoagulation
Fatal PE (7 months) · participants with diagnosed DVT
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the… (2023) · Cochrane
OR 1.32 [0.29, 6.02]3 studies · 5994 participantsModerate
Oral DTIs vs conventional anticoagulation
Non‐fatal PE (7 months) · participants with diagnosed DVT
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the… (2023) · Cochrane
OR 1.29 [0.64, 2.59]3 studies · 5994 participantsModerate
Oral DTIs vs conventional anticoagulation
All‐cause mortality (7 months) · participants with diagnosed DVT
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the… (2023) · Cochrane
OR 0.66 [0.41, 1.08]1 study · 2489 participantsModerate