Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 11 reviews · Pregnancy and Childbirth

No studies found 14 · 42.4%GRADE not reported 1 · 3%Very low 4 · 12.1%Low 6 · 18.2%Moderate 7 · 21.2%High 1 · 3%

Lower genital tract infection screening vs No screening

Preterm very low birthweight (below or equal 1500 g) · pregnant women presenting for routine prenatal care

Lower genital tract infection screening probably leads to lower preterm very low birthweight (below or equal 1500 g) compared with no screening (moderate certainty).

1 finding from 1 review

Lower genital tract infection screening vs No screening

Preterm low birthweight (below or equal 2500 g) · pregnant women presenting for routine prenatal care

Lower genital tract infection screening probably leads to lower preterm low birthweight (below or equal 2500 g) compared with no screening (moderate certainty).

1 finding from 1 review

Planned early birth vs expectant management

Major neonatal morbidity · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in major neonatal morbidity one or more of the following: hypoxic… compared with expectant management (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Significant maternal morbidity one or more of the following: significant postpartum haemorrhage requiring blood transfusion; maternal admission to intensive care unit; uterine rupture; hysterectomy · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in significant maternal morbidity one or more of the following:… compared with expectant management (low certainty).

1 finding from 1 review

Low‐cavity forceps vs any vacuum cup

Failed delivery with allocated instrument (primary) · Women in the second stage of labour, requiring an assisted vaginal birth

It is very uncertain whether low‐cavity forceps changes failed delivery with allocated instrument (primary) compared with any vacuum cup (very low certainty).

1 finding from 1 review

Additional support vs usual care

Satisfaction with pregnancy care Pregnancy care rated as "very helpful" · women at increased risk of low birthweight babies (maternal outcomes)

Additional support probably leads to higher satisfaction with pregnancy care Pregnancy care rated as "very… compared with usual care during pregnancy (moderate certainty).

1 finding from 1 review

Intervention not reported

Perinatal/neonatal death or severe neonatal morbidity ‐ Low national perinatal mortality rate · women with term breech delivery

The intervention probably leads to lower perinatal/neonatal death or severe neonatal morbidity ‐ Low national… (moderate certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Vaginal delivery not achieved within 24 hours · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) probably leads to higher vaginal delivery not achieved within 24 hours compared with low‐dose oral misoprostol (moderate certainty).

1 finding from 1 review

Discontinued intravenous (IV) oxytocin stimulation vs continued IV oxytocin stimulation

Apgar score less than 7 at 5 minutes · pregnant women in latent phase of labour stimulated with oxytocin for with induction of labour. No exclusion criteria were applied in…

Discontinued intravenous (IV) oxytocin stimulation may leads to lower apgar score at five minutes below seven compared with continued IV oxytocin stimulation (low certainty).

1 finding from 1 review

Foley catheter vs intravenous (IV) oxytocin

Vaginal delivery not achieved within 24 hours · pregnant women with a previous low transverse caesarean section, singleton live pregnancy with cephalic presentation, period of gestation…

Foley catheter showed no clear difference in vaginal delivery not achieved within 24 hours compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review

Vaginal isosorbide mononitrate vs Foley catheter

Vaginal delivery not achieved within 24 hours · pregnant women with 1 previous lower segment caesarean section at 37 weeks and beyond, with a BS of ≤ 6, intact membranes, reactive…

Vaginal isosorbide mononitrate may leads to higher vaginal delivery not achieved within 24 hours compared with foley catheter (low certainty).

1 finding from 1 review

80 mL vs Foley catheter

Vaginal delivery not achieved within 24 hours · pregnant women who previously had a lower segment CS and now have a singleton cephalic presentation after at least 36 completed weeks, not…

80 mL showed no clear difference in vaginal delivery not achieved within 24 hours compared with 30 mL Foley catheter (moderate certainty).

1 finding from 1 review

Intervention not reported

Preterm delivery < 37 weeks' gestation · women in late pregnancy (after 24 weeks' gestation) in both unselected populations and designated low‐risk populations

The intervention showed no clear difference in preterm delivery < 37 weeks' gestation (high certainty).

1 finding from 1 review

Intervention not reported

Preterm delivery less than 34 weeks · women in late pregnancy (after 24 weeks' gestation) in both unselected populations and designated low‐risk populations
1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Mortality due to bleeding ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review