Chronic lung disease · preterm infants
Very early treatment showed no clear difference in chronic lung disease compared with expectant management (low certainty).
1 finding from 1 review
Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants
Very early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (moderate certainty).
1 finding from 1 review
NEC ≥ stage II · preterm infants
Very early treatment showed no clear difference in necrotizing enterocolitis (NEC; stage 2 or greater) compared with expectant management (moderate certainty).
1 finding from 1 review
Duration of hospitalization · preterm infants
1 finding from 1 review
Neurodevelopmental outcomes (moderate/severe cognitive delay at 18 to 24 months) · preterm infants
Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe cognitive delay at 18… compared with expectant management (low certainty).
1 finding from 1 review
Neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24 months) · preterm infants
Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24… compared with expectant management (low certainty).
1 finding from 1 review
Neurodevelopmental outcomes (moderate/severe language delay at 18 to 24 months) · preterm infants
Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe language delay at 18 to… compared with expectant management (low certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · preterm infants
Very early treatment showed no clear difference in all‐cause mortality during hospital stay compared with expectant management (moderate certainty).
1 finding from 1 review
Proportion of infants requiring surgical PDA ligation or transcatheter occlusion · preterm infants
Very early treatment showed no clear difference in proportion of infants requiring surgical PDA ligation or… compared with expectant management (moderate certainty).
1 finding from 1 review
Proportion of infants receiving any pharmacotherapy for a hemodynamically significant PDA · preterm infants
It is very uncertain whether very early treatment changes proportion of infants receiving any pharmacotherapy for a… compared with expectant management (very low certainty).
1 finding from 1 review
Treatment failure; death · children with cancer
Very early discharge may leads to lower treatment failure; death compared with early discharge (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Duration of total antimicrobial treatment · children with cancer
Very early discharge may leads to lower duration of total antimicrobial treatment compared with early discharge (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Duration of intravenous antimicrobial treatment · children with cancer
Very early discharge may leads to lower duration of intravenous antimicrobial treatment compared with early discharge (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Duration of oral antimicrobial treatment · children with cancer
Very early discharge may leads to lower duration of oral antimicrobial treatment compared with early discharge (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both) in number of episodes · children with cancer
Very early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with early discharge (low certainty).
1 finding from 1 review
RR 0.54 [0.15, 1.89]
Studies not reported
Low
Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both), only first episode in number of participants · children with cancer
Very early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with early discharge (low certainty).
1 finding from 1 review
RR 0.32 [0.07, 1.4]
Studies not reported
Low
Failed Treatment · preterm infants
It is very uncertain whether prophylactic or very early CPAP changes failed treatment defined as recurrent apnoea, hypoxia, hypercarbia… compared with supportive care (very low certainty).
1 finding from 1 review
Recovered · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)
Specialised early intervention (SEI) may leads to higher global state: recovery (assessed by proportion recovered, as defined… compared with treatment (low certainty).
1 finding from 1 review
Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both) in number of episodes · children with cancer
Early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with non‐early discharge (low certainty).
1 finding from 1 review
RR 0.91 [0.24, 3.5]
Studies not reported
Low
Treatment failure; death · children with cancer
Early discharge may leads to lower treatment failure; death compared with non‐early discharge (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low