Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,411 questions · 2,571 findings · 265 reviews

No studies found 543 · 21.1%GRADE not reported 169 · 6.6%Very low 676 · 26.3%Low 731 · 28.4%Moderate 399 · 15.5%High 53 · 2.1%

Advance care planning vs usual care

Concordance between participants' preferences and end‐of‐life care (yes/no) Post‐death data: mean days to death, ACP group (388.8 ± 255.7); usual care group (362.2 ± 288.4) · people with heart failure with or without their surrogate decision‐makers/carers

It is very uncertain whether advance care planning changes concordance between participants' preferences and end‐of‐life care… compared with usual care (very low certainty).

1 finding from 1 review

PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease

Exacerbations · patients with chronic obstructive pulmonary disease

PPI plus usual care may leads to lower exacerbation rate (participants with one or more) study duration: 12… compared with usual care alone or chronic obstructive pulmonary disease (low certainty).

1 finding from 1 review

PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease

Acute respiratory infections study duration: 12 months · patients with chronic obstructive pulmonary disease

It is very uncertain whether PPI plus usual care changes acute respiratory infections study duration: 12 months compared with usual care alone or chronic obstructive pulmonary disease (very low certainty).

1 finding from 1 review

Exercise plus usual care vs usual care

Adherence to prescribed exercise programmes · cancer cachexia in adults

It is very uncertain whether exercise plus usual care changes adherence to prescribed exercise programmes compared with usual care (very low certainty).

1 finding from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Cardiovascular mortality · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)

Usual care with ivabradine showed no clear difference in mortality from cardiovascular causes ( compared with placebo, usual care, or no treatment (moderate certainty).

2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Time to first hospitalisation for heart failure during · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)

The review found no eligible studies for this question.

2 findings from 1 review