Blood loss > 400 mL or > 500 mL · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to lower blood loss > 400 mL or > 500 mL compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Blood loss > 1000 mL · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to lower blood loss > 1000 mL compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Mean blood loss (mL) · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
1 finding from 1 review
Use of additional medical interventions to control PPH · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to lower use of additional medical interventions to control PPH compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Serious maternal morbidity or death · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
1 finding from 1 review
Side effects · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to higher side effects compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Thromboembolic events · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid showed no clear difference in thromboembolic events compared with placebo/no treatment (low certainty).
1 finding from 1 review
Maternal mortality due to bleeding · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid showed no clear difference in maternal mortality due to bleeding compared with placebo or standard care alone (moderate certainty).
1 finding from 1 review
Maternal mortality ‐ not reported · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid showed no clear difference in maternal mortality (all causes) compared with placebo or standard care alone (moderate certainty).
1 finding from 1 review
Serious maternal morbidity · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid showed no clear difference in serious maternal morbidity (any) compared with placebo or standard care alone (high certainty).
1 finding from 1 review
Maternal blood loss of 500 mL or greater · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid may leads to lower blood loss 500 mL or more after randomisation compared with placebo or standard care alone (low certainty).
1 finding from 1 review
Blood transfusion · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid showed no clear difference in blood transfusion (any) compared with placebo or standard care alone (moderate certainty).
1 finding from 1 review
Hysterectomy to control bleeding · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid showed no clear difference in surgical intervention to control bleeding: Hysterectomy compared with placebo or standard care alone (high certainty).
1 finding from 1 review
Side effects of the intervention: Any maternal vascular occlusive event · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid showed no clear difference in side effects of the intervention: Any maternal vascular occlusive… compared with placebo or standard care alone (moderate certainty).
1 finding from 1 review