What do systematic reviews say?

Tranexamic acid vs placebo + standard care

Tranexamic acid probably leads to lower control of epistaxis: episodes of re‐bleeding over 10 days All… compared with placebo plus usual care or usual care alone (moderate certainty).

• Tranexamic acid for patients with nasal haemorrhage (epistaxis) 2018 · Cochrane Headline outcomes only
  RR 0.71 [0.56, 0.9]
  3 studies · 225 participants
  Moderate

Clotrimazole (partially absorbed from GI tract) vs another azole

It is very uncertain whether clotrimazole changes complete clinical resolution compared with another azole (very low certainty).

• Topical azole treatments for otomycosis 2021 · Cochrane Headline outcomes only
  RR 0.8 [0.59, 1.07]
  3 studies · 439 participants
  Very low

Clotrimazole (partially absorbed from GI tract) vs another azole

• Topical azole treatments for otomycosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 174 participants
  Very low

Clotrimazole (partially absorbed from GI tract) vs another azole

Clotrimazole showed no clear difference in mycological resolution compared with another azole (low certainty).

• Topical azole treatments for otomycosis 2021 · Cochrane Headline outcomes only
  RR 1.01 [0.96, 1.06]
  1 study · 174 participants
  Low

Clotrimazole (partially absorbed from GI tract) vs another azole

It is very uncertain whether clotrimazole changes other adverse events compared with another azole (very low certainty).

• Topical azole treatments for otomycosis 2021 · Cochrane Headline outcomes only
  RR 0.79 [0.18, 3.41]
  1 study · 174 participants
  Very low