What do systematic reviews say?

Thyroxine vs placebo or no treatment

Thyroxine led to lower adverse events including maternal pregnancy complications, foetal… compared with placebo or no treatment; GRADE not reported.

• Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 1 participants
  GRADE not reported

Thyroxine vs placebo or no treatment

Thyroxine showed no clear difference in live birth rate – euthyroid women with anti‐TPO antibodies compared with placebo or no treatment (low certainty).

• Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism 2019 · Cochrane Headline outcomes only
  RR 1.04 [0.83, 1.29]
  2 studies · 686 participants
  Low

Thyroxine vs placebo or no treatment

Thyroxine showed no clear difference in miscarriage – anti‐TPO antibodies compared with placebo or no treatment (low certainty).

• Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism 2019 · Cochrane Headline outcomes only
  RR 0.83 [0.47, 1.46]
  2 studies · 686 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The intervention showed no clear difference in adverse events (low certainty).

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  RR 1.78 [0.62, 5.12]
  3 studies · 104 participants
  Low

Intervention not reported

The intervention may leads to lower pressure symptoms / cosmetic complaints (low certainty).

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 370 participants
  Low

Intervention not reported

The intervention probably leads to higher nodule volume reduction ≥ 50% (moderate certainty).

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  RR 1.83 [1.32, 2.54]
  3 studies · 105 participants
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 97 participants
  Low

Intervention not reported

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 92 participants
  Low

Intervention not reported

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 62 participants
  Low

Intervention not reported

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 62 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Levothyroxine or minimally invasive therapies for benign thyroid nodules 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found