Cochrane · systematic review · CD011009
Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism
Akhtar, MA, Agrawal, R, Brown, J, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 33.3%Very low 0 · 0%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Thyroxine compared to placebo or no treatment for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism
Population: subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate – euthyroid women with anti‐TPO antibodies Thyroxine vs placebo or no treatment | RR 1.04 [0.83, 1.29] | 2 studies · 686 participants | Low Downgraded: imprecision |
Adverse events including maternal pregnancy complications, foetal complications and adverse effects of thyroxine Thyroxine vs placebo or no treatment | no estimate extracted | 0 studies · 1 participants | Ungraded |
Miscarriage – anti‐TPO antibodies Thyroxine vs placebo or no treatment | RR 0.83 [0.47, 1.46] | 2 studies · 686 participants | Low Downgraded: imprecision |