Cochrane · systematic review · CD004098
Levothyroxine or minimally invasive therapies for benign thyroid nodules
Bandeira‐Echtler, E, Bergerhoff, K, Richter, B · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
13
No studies
15
Included studies
NR
No studies 15 · 53.6%Ungraded 0 · 0%Very low 0 · 0%Low 11 · 39.3%Moderate 2 · 7.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings (levothyroxine treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality | no estimate extracted | NR | No studies |
Thyroid cancer | no estimate extracted | NR | Low Downgraded: imprecision |
Health‐related quality of life | no estimate extracted | NR | No studies |
Adverse events | no estimate extracted | 3 studies · 269 participants | Low Downgraded: risk of bias, inconsistency |
Pressure symptoms / cosmetic complaints | no estimate extracted | NR | No studies |
Nodule volume reduction ≥ 50% | RR 1.57 [1.04, 2.38] | 10 studies · 958 participants | Moderate Downgraded: indirectness |
Socioeconomic effects | no estimate extracted | NR | No studies |
Summary of findings (percutaneous ethanol injection sclerotherapy)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality | no estimate extracted | NR | No studies |
Thyroid cancer | no estimate extracted | NR | No studies |
Health‐related quality of life | no estimate extracted | NR | No studies |
Adverse events | RR 1.78 [0.62, 5.12] | 3 studies · 104 participants | Low Downgraded: risk of bias, imprecision |
Pressure symptoms / cosmetic complaints | no estimate extracted | 3 studies · 370 participants | Low Downgraded: risk of bias, inconsistency |
Nodule volume reduction ≥ 50% | RR 1.83 [1.32, 2.54] | 3 studies · 105 participants | Moderate Downgraded: indirectness |
Socioeconomic effects | no estimate extracted | NR | No studies |
Summary of findings (laser photocoagulation)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality | no estimate extracted | NR | No studies |
Thyroid cancer | no estimate extracted | NR | No studies |
Health‐related quality of life | no estimate extracted | NR | No studies |
Adverse events | no estimate extracted | 3 studies · 97 participants | Low Downgraded: risk of bias, inconsistency |
Pressure symptoms / cosmetic complaints | no estimate extracted | 3 studies · 92 participants | Low Downgraded: risk of bias, imprecision |
Nodule volume reduction ≥ 50% | no estimate extracted | 1 study · 62 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Socioeconomic effects | no estimate extracted | 1 study · 62 participants | Low Downgraded: imprecision |
Summary of findings (radiofrequency ablation)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality | no estimate extracted | NR | No studies |
Thyroid cancer | no estimate extracted | NR | No studies |
Health‐related quality of life | no estimate extracted | NR | No studies |
Adverse events | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
Pressure symptoms / cosmetic complaints | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
Nodule volume reduction ≥ 50% | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
Socioeconomic effects | no estimate extracted | NR | No studies |