Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 21 findings · 3 reviews

No studies found 0 · 0%GRADE not reported 10 · 47.6%Very low 5 · 23.8%Low 5 · 23.8%Moderate 1 · 4.8%High 0 · 0%

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Trifluoperazine showed no clear difference in leaving the study early: 1. Acceptability of treatment ‐ leaving… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects/events: at least 1 adverse effect ‐ as defined by individual studies. · patients with schizophrenia

Trifluoperazine showed no clear difference in adverse events: 1. General ‐ at least one adverse effect compared with low‐potency antipsychotic drugs (moderate certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects ‐ movement disorders ‐ At least one movement disorder · patients with schizophrenia

Trifluoperazine showed no clear difference in adverse events: 2.a. Specific ‐ movement disorders ‐ at least one… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Global state ‐ clinical improvement ‐ medium term As defined by each study · patients with schizophrenia

TRIFLUOPERAZINE may leads to higher global state ‐ clinical improvement ‐ medium term As defined by each… compared with PLACEBO (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Global state ‐ relapse or worsening ‐ medium term Numbers of participants experiencing relapse/worsening · patients with schizophrenia

TRIFLUOPERAZINE may leads to lower global state ‐ relapse or worsening ‐ medium term Numbers of… compared with PLACEBO (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Mental state ‐ any clinically significant response in psychotic symptoms (as defined by each study) ‐ medium term Numbers of participants experiencing 'intensified symptoms' · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes mental state ‐ any clinically significant response in psychotic… compared with PLACEBO (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes leaving the study early ‐ any reason ‐ medium term Number of… compared with PLACEBO (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Severe adverse effects ‐ short term Numbers of participants leaving the studies due to severe adverse effects · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes severe adverse effects ‐ short term Numbers of participants leaving… compared with PLACEBO (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Behaviour ‐ any clinically significant agitation or distress ‐ medium term As defined by each study · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes behaviour ‐ any clinically significant agitation or distress ‐… compared with PLACEBO (very low certainty).

1 finding from 1 review