HIV infection · High‐risk individuals (including serodiscordant couples, men who have sex with men and sex workers)
TDF probably leads to lower HIV infection compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · High‐risk individuals (including serodiscordant couples, men who have sex with men and sex workers)
TDF showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · patients with initial ART
TDF showed no clear difference in serious adverse events compared with AZT (high certainty).
1 finding from 1 review
Virologic response · patients with initial ART
TDF showed no clear difference in virologic response compared with AZT (high certainty).
1 finding from 1 review
Adherence/tolerability/retention · patients with initial ART
TDF probably leads to higher adherence/tolerability/retention compared with AZT (moderate certainty).
1 finding from 1 review
Immunological response · patients with initial ART
1 finding from 1 review
Drug resistance · patients with initial ART
It is very uncertain whether TDF changes drug resistance compared with AZT (very low certainty).
1 finding from 1 review
HIV infection · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers)
TDF+ FTC probably leads to lower HIV infection compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers)
TDF+ FTC showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review