Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 32 findings · 4 reviews

No studies found 8 · 25%GRADE not reported 0 · 0%Very low 4 · 12.5%Low 20 · 62.5%Moderate 0 · 0%High 0 · 0%

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of S aureus (sensitive strains) · children with cystic fibrosis

Summary of findings ‐ Prophylactic may leads to lower number of people with one or more isolates of S aureus (sensitive… compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of P aeruginosa · children with cystic fibrosis

Summary of findings ‐ Prophylactic showed no clear difference in number of people with one or more isolates of P aeruginosa compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Need for additional antibiotic therapy · children with cystic fibrosis

Summary of findings ‐ Prophylactic showed no clear difference in number of people needing additional antibiotics compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Death · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes death compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Venous thromboembolism · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes venous thromboembolism compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Intracerebral haemorrhage (ICH) · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes intracerebral haemorrhage (ICH) compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Functional status: mRS 0‐2 · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes functional status: mRS 0‐2 compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Requirement of other courses of antibiotics · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in requirement of other courses of antibiotics compared with continuation (low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Incidence of S pneumoniae Confirmed bacterial infection · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in incidence of S pneumoniae Confirmed bacterial infection compared with continuation (low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Adverse event nausea and vomiting (0 to 24 hours) · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in gastrointestinal side effects (nausea and/or vomiting) compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review