Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

36 questions · 39 findings · 7 reviews · Neonatal

No studies found 6 · 15.4%GRADE not reported 1 · 2.6%Very low 13 · 33.3%Low 15 · 38.5%Moderate 4 · 10.3%High 0 · 0%

Continuous glucose monitoring system vs intermittent modalities

All‐cause mortality during initial hospitalization ‐ not reported · infants at risk of hypoglycaemia or hyperglycaemia

It is very uncertain whether summary of findings table ‐ Continuous glucose monitoring (CGM) changes death during initial hospitalization (all‐cause mortality) compared with intermittent modalities (very low certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Risk of necrotising enterocolitis stage ≥ 2 · preterm infants

Summary of findings table ‐ routine monitoring showed no clear difference in risk of necrotising enterocolitis stage ≥ 2 compared with no routine monitoring of gastric residual (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Number of infants with feed interruption episodes (lasting ≥ 12 hours) · preterm infants

Summary of findings table ‐ routine monitoring may leads to higher number of infants with feed interruption episodes (lasting ≥ 12 hours) compared with no routine monitoring of gastric residual (low certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Risk of invasive Infection · preterm infants

Summary of findings table ‐ routine monitoring probably leads to higher risk of invasive infection compared with no routine monitoring of gastric residual (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Mortality before hospital discharge · preterm infants

Summary of findings table ‐ routine monitoring showed no clear difference in all‐cause mortality before hospital discharge compared with no routine monitoring of gastric residual (low certainty).

1 finding from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Growth during the first month of life · preterm born neonates
3 findings from 1 review

Summary of findings table ‐ Silicone earplugs vs no earplugs

All‐cause mortality during hospital stay · preterm or very low birth weight infants

It is very uncertain whether summary of findings table ‐ Silicone earplugs changes all‐cause mortality during hospital stay compared with no earplugs (very low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period compared with control (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG compared with control (very low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period ‐ IgG · preventing necrotizing enterocolitis in preterm and low birth weight neonates

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period ‐ IgG compared with control (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

NEC‐related surgery during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes NEC‐related surgery during study period compared with control (very low certainty).

1 finding from 1 review