Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 5 reviews

No studies found 3 · 20%GRADE not reported 0 · 0%Very low 3 · 20%Low 7 · 46.7%Moderate 1 · 6.7%High 1 · 6.7%

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

1 finding from 1 review · compare the 2 reviews

Intervention not reported

Live birth or ongoing pregnancy Short protocol vs long protocol · subfertile women

The intervention showed no clear difference in live birth or ongoing pregnancy Short protocol vs long protocol (low certainty).

1 finding from 1 review

Long protocol vs short protocol

Ongoing pregnancy / live birth rate per woman · women undergoing pituitary suppression in assisted reproduction

Long protocol showed no clear difference in live birth or ongoing pregnancies per woman randomised compared with short protocol (low certainty).

1 finding from 1 review

Intervention not reported

Live birth/ongoing pregnancy ‐ short vs long protocol · subfertile women

The intervention showed no clear difference in live birth/ongoing pregnancy ‐ short vs long protocol (low certainty).

1 finding from 1 review

Intervention not reported

OHSS ‐ short vs long protocol · subfertile women

The review found no eligible studies for this question.

1 finding from 1 review

Anticholinergic and short‐acting beta2‐agonists vs B2‐agonists alone

Hospital admissions · children with initial treatment of acute asthma

Anticholinergic and short‐acting beta2‐agonists leads to lower primary outcome: hospital admissions hospital admissions compared with beta2‐agonists alone (all protocols) (high certainty).

1 finding from 1 review