Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

105 questions · 107 findings · 15 reviews

No studies found 3 · 2.8%GRADE not reported 13 · 12.1%Very low 36 · 33.6%Low 30 · 28%Moderate 23 · 21.5%High 2 · 1.9%

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

All‐cause mortality · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in mortality compared with prolonged‐course antibiotic therapy be used (moderate certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Mortality NF‐GNB · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in mortality NF‐GNB compared with prolonged‐course antibiotic therapy be used (low certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Mortality MRSA · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in mortality MRSA compared with prolonged‐course antibiotic therapy be used (moderate certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Recurrence of pneumonia · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in recurrence of pneumonia Clinical and/or microbiological criteria compared with prolonged‐course antibiotic therapy be used (low certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Recurrence of pneumonia ‐ NF‐GNB · hospital‐acquired pneumonia

Should short‐course antibiotic therapy probably leads to higher recurrence of pneumonia NF‐GNB Clinical and/or microbiological… compared with prolonged‐course antibiotic therapy be used (moderate certainty).

1 finding from 1 review

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Recurrence of pneumonia ‐ MRSA · hospital‐acquired pneumonia

Should short‐course antibiotic therapy showed no clear difference in recurrence of pneumonia MRSA Clinical and/or microbiological criteria compared with prolonged‐course antibiotic therapy be used (moderate certainty).

1 finding from 1 review

Short‐acting inhaled beta‐2 agonists vs placebo

Number of exacerbations(as reported by number of hospitalisations and number of courses and days on antibiotics) · adults and children with cystic fibrosis

It is very uncertain whether short‐acting inhaled beta‐2 agonists changes number of exacerbations(as reported by number of hospitalisations… compared with placebo (very low certainty).

1 finding from 1 review