Findings

What do systematic reviews say?

52 questions · 52 findings · 7 reviews

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No studies found 11 · 21.2%GRADE not reported 4 · 7.7%Very low 12 · 23.1%Low 7 · 13.5%Moderate 2 · 3.8%High 16 · 30.8%

Selenium vs placebo

Change in selenium concentrations (µg/L) · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 527 participants
Low

Selenium vs placebo

Incidence: lung cancer · healthy men

Selenium showed no clear difference in incidence: lung cancer compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.11 [0.8, 1.54]
1 study · 17448 participants
High

Selenium vs placebo

Mortality: lung cancer · healthy men

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
1.09 [0.72, 1.66]
1 study · 17448 participants
High

Selenium vs placebo

Alopecia · healthy men

Selenium leads to higher adverse events: alopecia compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.28 [1.07, 1.53]
1 study · 17448 participants
High

Selenium vs placebo

adverse events: grade 1 to 2 dermatitis · healthy men

Selenium leads to higher adverse events: grade 1 to 2 dermatitis compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.16 [1.04, 1.31]
1 study · 17448 participants
High

Selenium vs placebo

Incidence: all cancers · healthy men

Selenium showed no clear difference in incidence: all cancers compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.01 [0.92, 1.11]
1 study · 17448 participants
High

Selenium vs placebo

Mortality: all cancers · healthy men

Selenium showed no clear difference in mortality: all cancers compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.02 [0.8, 1.3]
1 study · 17448 participants
High

Selenium vs placebo

Mortality: all causes · healthy men

Selenium showed no clear difference in mortality: all causes compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 0.98 [0.86, 1.13]
1 study · 17448 participants
High

Selenium vs no intervention

Dry mouth (xerostomia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
6 weeks after end of RT
No evidence that selenium reduced xerostomia; data unusable (bar charts with no standard deviations) (Buntzel 2010)
1 study
GRADE not reported

Selenium vs no intervention

Survival · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No survival data were reported.
0 studies
No studies found

Selenium vs no intervention

Quality of life and other oral related symptoms (loss of taste, dysphagia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
6 weeks after end of RT
Insufficient evidence of differences for loss of taste or dysphagia; data largely unusable (no standard deviations). Ageusia milder in selenium group (not significant); dysphagia significant only at week 7 (P = 0.05)…
1 study
GRADE not reported

Selenium vs placebo

All‐cause mortality · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Selenium vs placebo

Hospital admissions · adults with HIV infection

It is very uncertain whether selenium changes hospital admissions compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
RR 0.4 [0.21, 0.75]
1 study · 186 participants
Very low

Selenium vs placebo

Change in CD4 count · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1187 participants
Low

Selenium vs placebo

Change in viral load · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 439 participants
Low

Selenium vs no intervention

Side effects · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
6 weeks after end of RT
23 serious adverse events in the selenium group versus 22 in the control group (P = 0.476); no significant differences in toxicities (Buntzel 2010)
1 study
GRADE not reported

Selenium vs no intervention

Salivary flow rate · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on salivary flow rates were reported.
0 studies
No studies found

Selenium (+LT4) vs placebo (+LT4)

Change from baseline in health‐related quality of life · participants with Hashimoto's thyroiditis.

The review found no eligible studies for this question.

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selenium (+LT4) vs placebo (+LT4)

Change from baseline in assessment of symptoms such as mood, fatigue and muscle weakness Short‐Form Health Survey · participants with Hashimoto's thyroiditis.

Selenium (+LT4) may leads to higher change from baseline in assessment of symptoms such as mood, fatigue… compared with placebo (+LT4) (low certainty).

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
RR 4.67 [1.61, 13.5]
1 study · 36 participants
Low

Selenium (+LT4) vs placebo (+LT4)

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · participants with Hashimoto's thyroiditis.

Selenium (+LT4) showed no clear difference in proportion of participants reporting an adverse event compared with placebo (+LT4) (low certainty).

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
RR 2.71 [0.29, 25.66]
3 studies · 258 participants
Low