Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews · Gut · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 2 · 33.3%High 0 · 0%

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Death Analysis 1.1 · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in all‐cause mortality, ITT analysis compared with early conservative management with or without delayed or selective… (low certainty).

1 finding from 1 review

Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in… 2012 · Cochrane Headline outcomes only
RR 0.74 [0.18, 3.03]
5 studies · 644 participants
Low

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Local complications defined by the Atlanta Classification (necrosis, abscess, pseudocyst) · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in local complications defined by the Atlanta Classification (necrosis,… compared with early conservative management with or without delayed or selective… (moderate certainty).

1 finding from 1 review

Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in… 2012 · Cochrane Headline outcomes only
RR 0.86 [0.52, 1.43]
4 studies · 517 participants
Moderate

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Systemic complications defined by the Atlanta Classification (organ failure including shock, pulmonary insufficiency, renal failure, and gastrointestinal bleeding; disseminated intravascular coagulation or severe metabolic disturbances) · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in systemic complications defined by the Atlanta Classification (organ… compared with early conservative management with or without delayed or selective… (moderate certainty).

1 finding from 1 review

Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in… 2012 · Cochrane Headline outcomes only
RR 0.59 [0.31, 1.11]
4 studies · 406 participants
Moderate

Etoricoxib vs placebo

Exacerbation of IBD · IBD patients

Etoricoxib showed no clear difference in exacerbation of IBD compared with placebo (low certainty).

1 finding from 1 review

Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of… 2014 · Cochrane Headline outcomes only
RR 0.88 [0.45, 1.69]
1 study · 159 participants
Low

Celecoxib vs placebo

Exacerbation of ulcerative colitis · Patients with quiescent ulcerative colitis

Celecoxib showed no clear difference in exacerbation of ulcerative colitis compared with placebo (low certainty).

1 finding from 1 review

Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of… 2014 · Cochrane Headline outcomes only
RR 0.7 [0.23, 2.14]
1 study · 222 participants
Low

Celecoxib vs placebo

GI adverse events · Patients with quiescent ulcerative colitis

Celecoxib showed no clear difference in GI adverse events compared with placebo (low certainty).

1 finding from 1 review

Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of… 2014 · Cochrane Headline outcomes only
RR 0.97 [0.46, 2.07]
1 study · 221 participants
Low