Findings

What do systematic reviews say?

41 questions · 42 findings · 6 reviews · ENT

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No studies found 20 · 47.6%GRADE not reported 0 · 0%Very low 7 · 16.7%Low 10 · 23.8%Moderate 5 · 11.9%High 0 · 0%

Saline vs no saline treatment

Disease severity score (up to 4 weeks) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Saline vs no saline treatment

Disease severity score (4 weeks to 6 months) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Saline vs no saline treatment

Individual symptom scores ‐ not measured · allergic rhinitis

The review found no eligible studies for this question.

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Saline vs no saline treatment

Epistaxis · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Saline vs no saline treatment

Disease‐specific quality of life · allergic rhinitis

2 findings from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low
Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Saline vs no saline treatment

Other adverse effects: local irritation · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Individual symptom scores ‐ not measured · allergic rhinitis

The review found no eligible studies for this question.

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Adverse effects ‐ epistaxis · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Health‐related quality of life (4 weeks to 6 months) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Other adverse effects: local irritation · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Disease severity score (up to 4 weeks) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Disease severity score (4 weeks to 6 months) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Ear drops (water or saline) vs no treatment

Proportion of patients (or ears) with complete clearance of ear wax · adults and children with ear wax requiring removal

Ear drops (water or saline) may leads to higher proportion of patients (or ears) with complete clearance of ear wax compared with no treatment (low certainty).

1 finding from 1 review

Ear drops for the removal of ear wax 2018 · Cochrane Headline outcomes only
RR 4
1 study · 48 participants
Low

Ear drops (water or saline) vs no treatment

Discomfort/pain · adults and children with ear wax requiring removal

Ear drops (water or saline) may leads to lower adverse effects: discomfort, irritation or pain compared with no treatment (low certainty).

1 finding from 1 review

Ear drops for the removal of ear wax 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Tranexamic acid vs placebo (saline solution or sterile water)

Surgical field bleeding score (during surgery or < 30 minutes after surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 772 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Intraoperative blood loss (mL) · adults and children with chronic rhinosinusitis with or without nasal polyps

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 802 participants
Low

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
RD 0
8 studies · 664 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Duration of surgery (minutes) Assessed as: total surgical time · adults and children with chronic rhinosinusitis with or without nasal polyps

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 666 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Incomplete surgery · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in incomplete surgery compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
RD 0
2 studies · 58 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Overall rate of surgical complications · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in surgical complications compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
RD 0
2 studies · 58 participants
Moderate