Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

59 questions · 59 findings · 12 reviews · Kidney and Transplant

No studies found 7 · 11.9%GRADE not reported 1 · 1.7%Very low 16 · 27.1%Low 23 · 39%Moderate 12 · 20.3%High 0 · 0%

Short duration (3 to 4 days) vs long duration (7 to 14 days) IV therapy

Persistent renal damage at 3 to 6 months: all included children with acute pyelonephritis · children with acute pyelonephritis

Short duration (3 to 4 days) showed no clear difference in persistent renal damage at 3 to 6 months: all included children with… compared with long duration (7 to 14 days) IV therapy (moderate certainty).

1 finding from 1 review

Short duration (3 to 4 days) vs long duration (7 to 14 days) IV therapy

Persistent renal damage at 3 to 6 months: children with initial renal parenchymal damage on initial DMSA scan · children with acute pyelonephritis

Short duration (3 to 4 days) showed no clear difference in persistent renal damage at 3 to 6 months: children with initial… compared with long duration (7 to 14 days) IV therapy (moderate certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Cure: short‐term success · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics plus antibiotic lock solutions plus tissue… changes cure: short‐term success compared with systemic antibiotics plus antibiotic lock solutions plus heparin (very low certainty).

1 finding from 1 review