Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Calculus · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in calculus at 7 months (Volpe-Manhold Calculus Index, mean height of… compared with fluoride toothpaste without triclosan; GRADE not reported.
2 findings from 1 review
Participant-centred outcomes (quality of life; satisfaction with product) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
The review found no eligible studies for this question.
1 finding from 1 review
Plaque · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
Triclosan/copolymer-containing fluoride toothpaste probably leads to lower plaque at 6 to 7 months (Quigley-Hein Plaque Index, 0 to 5 scale) compared with fluoride toothpaste without triclosan (moderate certainty).
3 findings from 1 review
MD -0.47 [-0.60, -0.34]
20 studies · 2675 participants
Moderate
MD -0.15 [-0.20, -0.10]
13 studies · 1850 participants
Moderate
MD -0.05 [-0.10, -0.01]
2 studies · 148 participants
GRADE not reported
Dental caries: prevalence of root caries · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
Triclosan/copolymer-containing fluoride toothpaste probably leads to lower root caries at 36 months (Katz Root Caries Index) compared with fluoride toothpaste without triclosan (moderate certainty).
1 finding from 1 review
Gingival bleeding (various bleeding indices) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
Triclosan/copolymer-containing fluoride toothpaste probably leads to lower gingival bleeding at 6 to 7 months (Gingivitis Severity Index,… compared with fluoride toothpaste without triclosan (moderate certainty).
2 findings from 1 review
Gingivitis · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
Triclosan/copolymer-containing fluoride toothpaste probably leads to lower gingivitis at 6 to 9 months (Loe-Silness Gingival Index, 0 to 3 scale) compared with fluoride toothpaste without triclosan (moderate certainty).
1 finding from 1 review
Coronal caries increment · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in coronal caries increment at 30 to 36 months (decayed filled teeth,… compared with fluoride toothpaste without triclosan (high certainty).
2 findings from 1 review
Tooth staining/discolouration (adverse effect) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in adverse effects (tooth staining, Meckel Stain Score, 6 months) compared with fluoride toothpaste without triclosan; GRADE not reported.
1 finding from 1 review
Periodontitis (clinical attachment loss) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…
Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in periodontitis at 36 months (attachment loss > 0 mm) compared with fluoride toothpaste without triclosan (low certainty).
1 finding from 1 review
Change in probing pocket depth (>=4 mm) · Adults with dental implants and peri-implant mucositis at baseline
Triclosan dentifrice showed no clear difference in change in probing pocket depth (>=4 mm) compared with sodium fluoride dentifrice; GRADE not reported.
1 finding from 1 review
Plaque · Adults with dental implants and peri-implant mucositis at baseline
Triclosan dentifrice showed no clear difference in plaque compared with sodium fluoride dentifrice; GRADE not reported.
1 finding from 1 review
Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
It is very uncertain whether dual zinc + arginine dentifrice changes dentist-reported OLT hedonic rating (scale 1 to 9) compared with control (regular fluoride) dentifrice (very low certainty).
1 finding from 1 review
Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy
Norfloxacin plus amphotericin B showed no clear difference in oral candidiasis (present) compared with amphotericin B; GRADE not reported.
1 finding from 1 review
Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy
Norfloxacin plus amphotericin B showed no clear difference in systemic fungal infection compared with amphotericin B; GRADE not reported.
1 finding from 1 review
Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year
1 finding from 1 review
Primary pairwise data unusable (implant numbers per surface not disclosed); one turned implant failed early. Data used only for the turned-vs-roughened secondary analysis (Wennstrom 2004)
1 study · 51 participants
GRADE not reported
Volatile sulphur compounds (VSC), gas chromatography · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Ferric sulphate (FS)
Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Assessed pain, soft tissue, mobility, adjacent tissue inflammation, radiolucency, root resorption, pulp canal obliteration (Doyle 2010); no clinical/radiological failure outcome; no significant differences
1 study · 135 participants
GRADE not reported
Caries lesion initiation/progression (ICDAS score, laser fluorescence/DIAGNOdent, photographic pixels, enamel acid resistance) · Patients (children and adults, age 3-40 years) with initial enamel caries lesions (non-orthodontic and orthodontic)
No meta-analysis was possible for the 5 in vivo RCTs (high heterogeneity); narratively nHA showed generally no significant difference versus fluoridated dentifrice, and the evidence was not graded (ungraded).
1 finding from 1 review
Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomesMedian follow-up 6 months (range 6-12 months) · In vivo (clinical); non-orthodontic and orthodontic patients
No meta-analysis was performed for the in vivo studies owing to high heterogeneity (population, control group, outcomes, follow-up periods, risk of bias) and differing statistical designs (e.g., non-inferiority);…
5 studies · 420 participants
GRADE not reported