Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

132 questions · 133 findings · 16 reviews · Kidney and Transplant · Headline outcomes only

No studies found 41 · 30.8%GRADE not reported 1 · 0.8%Very low 24 · 18%Low 51 · 38.3%Moderate 15 · 11.3%High 1 · 0.8%

Amphotericin B deoxycholate vs liposomal amphotericin B: effects on kidney function

Increase in SCr level: ≥ two‐fold from baseline level SCr level (mg/dL) · patients in treatment with amphotericin B

Amphotericin B deoxycholate probably leads to lower increase in SCr level: ≥ two‐fold from baseline level SCr level… compared with liposomal amphotericin B: effects on kidney function (moderate certainty).

1 finding from 1 review

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Cardiovascular events · people with CKD

Uric acid lowering therapies (UAR) showed no clear difference in cardiovascular events compared with placebo, no treatment or usual care (low certainty).

1 finding from 1 review

Upper limb exercise training vs control (no intervention/usual care/isotonic exercise)

Vascular access complications · CKD patients who underwent AVF creation

It is very uncertain whether upper limb exercise training changes vascular access complications (isometric versus isotonic exercise… compared with control (no intervention/usual care/isotonic exercise) (very low certainty).

1 finding from 1 review

Upper limb exercise training vs control (no intervention/usual care/isotonic exercise)

Ultrasound maturation (isometric versus isotonic exercise training) · CKD patients who underwent AVF creation

Upper limb exercise training may leads to higher ultrasound maturation (isometric versus isotonic exercise training) compared with control (no intervention/usual care/isotonic exercise) (low certainty).

1 finding from 1 review

Upper limb exercise training vs control (no intervention/usual care/isotonic exercise)

Clinical maturation (isometric versus isotonic exercise training) · CKD patients who underwent AVF creation

Upper limb exercise training may leads to higher clinical maturation (isometric versus isotonic exercise training) compared with control (no intervention/usual care/isotonic exercise) (low certainty).

1 finding from 1 review