Caries lesion initiation/progression (ICDAS score, laser fluorescence/DIAGNOdent, photographic pixels, enamel acid resistance) · Patients (children and adults, age 3-40 years) with initial enamel caries lesions (non-orthodontic and orthodontic)
No meta-analysis was possible for the 5 in vivo RCTs (high heterogeneity); narratively nHA showed generally no significant difference versus fluoridated dentifrice, and the evidence was not graded (ungraded).
1 finding from 1 review
Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomesMedian follow-up 6 months (range 6-12 months) · In vivo (clinical); non-orthodontic and orthodontic patients
No meta-analysis was performed for the in vivo studies owing to high heterogeneity (population, control group, outcomes, follow-up periods, risk of bias) and differing statistical designs (e.g., non-inferiority);…
5 studies · 420 participants
GRADE not reported
Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) may not differ from Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) for arrest or reversal of facial/lingual carious lesions (RR 1.28, 95% CI 0.97 to 1.68; low certainty).
3 findings from 1 review
Caries increment, surface index D(M)FS · Children or adolescents
In the illustrative network meta-regression the SMD for caries increment differed between fluoride in dentifrice and placebo at every displayed randomization year; certainty was not graded.
1 finding from 1 review
Caries increment, surface index D(M)FS · Children or adolescents
In the illustrative network meta-regression the SMD for caries increment differed between fluoride in dentifrice and no treatment at every displayed randomization year; certainty was not graded.
1 finding from 1 review
Caries increment in permanent teeth · Children or adolescents
The NMR reported a difference between fluoride in dentifrice and placebo at every displayed randomisation year; no GRADE assessment was reported.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Caries increment in permanent teeth · Children or adolescents
The NMR reported a difference between fluoride in dentifrice and no treatment at every displayed randomisation year; no GRADE assessment was reported.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy)
Platelet-rich fibrin and calcium hydroxide showed no significant difference in success (ungraded; effect size not reported).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth undergoing pulpotomy
The two trials of PRF versus MTA for success gave contradictory results and were not pooled (ungraded).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy
MTA and CEM performed comparably for clinical and radiographic success (2 RCTs, not pooled; ungraded).
1 finding from 1 review
Sensitivity for detection of enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)
Electrical conductance or impedance had a summary sensitivity of 0.83 (95% CrI 0.66, 0.92) for detecting enamel caries; low certainty.
1 finding from 1 review
Specificity for detection of enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)
Electrical conductance or impedance had a summary specificity of 0.72 (95% CrI 0.44, 0.89) for detecting enamel caries; low certainty.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
CEM and calcium hydroxide did not differ significantly in pulpotomy success (indirect comparison); ungraded.
1 finding from 1 review
Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients
Under demineralizing conditions, nHA allowed significantly more enamel demineralization than NaF (MD 1625, 95% CI 553 to 2697; very low certainty).
2 findings from 1 review
Recurrent caries (crowns free of recurrent caries) · Children with primary (deciduous) teeth requiring full-coverage crown restoration
Recurrent caries did not differ between zirconia crowns and other restorations at 6 months (RR 1.00, 95% CI 0.97 to 1.03; 2 studies; not GRADE-rated).
2 findings from 1 review
Crown retention · Children with primary (deciduous) teeth requiring full-coverage crown restoration
Zirconia crowns showed no significant difference in crown retention versus other restorations at 6 months (RR 1.02, 95% CI 0.94 to 1.11; 3 studies; not GRADE-rated).
2 findings from 1 review
Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients
Under remineralizing conditions, nHA produced significantly more remineralization than the negative control (MD 350, 95% CI 179 to 521; very low certainty).
2 findings from 1 review
Overall success (composite of clinical and radiographic success) · Adults (18-45 y) with mature permanent molars, carious exposure and symptomatic irreversible pulpitis
Restricting the lateral extent of partial pulpotomy gives success equivalent to more extensive amputation (97.6% vs 97.5%, p>0.05; ungraded, single trial).
1 finding from 1 review
Postoperative pain and analgesic intake · Adults (18-45 y) with mature permanent molars, carious exposure and symptomatic irreversible pulpitis
Restricted partial pulpotomy causes less early postoperative pain and analgesic use than extended amputation (p<0.05; ungraded, single trial).
1 finding from 1 review
Same RCT (Ramani 2024): restricted PP had significantly lower postoperative pain scores on days 1 and 2 (p<0.05) and required significantly less analgesic intake (p<0.05) than extended PP.
1 study · 96 participants
GRADE not reported
Water samples with fluoride concentration below the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control)
In the Northeast Brazilian region, a pooled 79.7% of water samples had fluoride below the acceptable range; ungraded.
2 findings from 1 review
Water samples with fluoride concentration above the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control)
In the Southeast Brazilian region, a pooled 11.5% of water samples had fluoride above the acceptable range; ungraded.
2 findings from 1 review