Fluoride-free nano-hydroxyapatite (nHA) dentifrice/paste vs Sodium fluoride (control) toothpaste: Mineral loss (transversal microradiography)
Under demineralizing conditions, nHA allowed significantly more enamel demineralization than NaF (MD 1625, 95% CI 553 to 2697; very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Fluoride-free nano-hydroxyapatite (nHA) dentifrice/paste vs Fluoridated control (sodium fluoride, NaF) Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by… · Median 21 days (range 14-28 days), In situ (intraoral appliance); net-demineralizing model, Net-demineralizing conditions Under demineralizing conditions, nHA allowed significantly more enamel demineralization than NaF (MD 1625, 95% CI 553 to 2697; very low certainty). Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. (2022) All outcomes | MD 1625 [553, 2697] | 1 study | Very low |
Fluoride-free nano-hydroxyapatite (nHA) dentifrice/paste vs Fluoridated control (sodium fluoride, NaF) Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by… · Median 21 days (range 14-28 days), In situ (intraoral appliance); net-remineralizing model, Net-remineralizing conditions Under remineralizing conditions, nHA and NaF had the same remineralizing potential (MD -15, 95% CI -133 to 103; no significant difference; very low certainty). Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. (2022) All outcomes | MD -15 [-133, 103] | 2 studies | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomes | Databases searched up to 30 April 2021 (CENTRAL up to 30 Apr 2021; MEDLINE/PubMed 1946 to 30 Apr 2021; Ovid EMBASE 1947 to 30 Apr 2021) | 10 | Low / Critically Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children. · 2019 · included by 1 of these review
- Remineralization of early caries by a nano-hydroxyapatite dentifrice. · 2011 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.