Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

39 questions · 39 findings · 4 reviews · Gut

No studies found 3 · 7.7%GRADE not reported 1 · 2.6%Very low 0 · 0%Low 17 · 43.6%Moderate 16 · 41%High 2 · 5.1%

Proton pump inhibitors (PPI) vs placebo or no prophylaxis

Clinically important upper GI bleeding · people admitted to intensive care units

Proton pump inhibitors showed no clear difference in clinically important upper GI bleeding compared with placebo or no prophylaxis (low certainty).

1 finding from 1 review