Cochrane · systematic review · CD011194
Proton pump inhibitors for functional dyspepsia
Pinto‐Sanchez, MI, Yuan, Y, Hassan, A, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 8.3%Very low 0 · 0%Low 2 · 16.7%Moderate 9 · 75%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsProton pump inhibitors (PPI) compared to placebo for functional dyspepsia
Population: functional dyspepsia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global symptoms of dyspepsia (> 2 weeks) Proton pump inhibitors (PPI) vs placebo | RR 0.88 [0.82, 0.94] | 18 studies · 6172 participants | Moderate Downgraded: inconsistency |
Quality of life Psychological General Well‐Being Index (Scale from: 22 to 132) and SF‐36 (Scale from: 0 to 100) combined Proton pump inhibitors (PPI) vs placebo | no estimate extracted | 3 studies · 1630 participants | Moderate Downgraded: imprecision, inconsistency |
Adverse events Proton pump inhibitors (PPI) vs placebo | RR 0.99 [0.73, 1.33] | 6 studies · 2693 participants | Moderate Downgraded: inconsistency |
Proton pump inhibitors (PPI) compared to H2 receptor antagonists (H2RA) for functional dyspepsia
Population: adults with functional dyspepsia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global symptoms of dyspepsia Proton pump inhibitors (PPI) vs H2 receptor antagonists (H2RA) | RR 0.88 [0.74, 1.04] | 2 studies · 740 participants | Low Downgraded: imprecision, inconsistency |
Quality of life Proton pump inhibitors (PPI) vs H2 receptor antagonists (H2RA) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse events Proton pump inhibitors (PPI) vs H2 receptor antagonists (H2RA) | RR 0.97 [0.64, 1.46] | 1 study · 589 participants | Moderate Downgraded: risk of bias |
Proton pump inhibitors (PPI) compared to prokinetics for functional dyspepsia
Population: adults with functional dyspepsia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global symptoms of dyspepsia Proton pump inhibitors (PPI) vs prokinetics | RR 0.89 [0.81, 0.99] | 5 studies · 1033 participants | Low Downgraded: imprecision |
Quality of life Korean version of the dyspepsia related Nepean Dyspepsia Index (NDI) from: 0 to 99 Proton pump inhibitors (PPI) vs prokinetics | no estimate extracted | 1 study · 262 participants | Moderate Downgraded: imprecision |
Adverse events Proton pump inhibitors (PPI) vs prokinetics | RR 1.09 [0.79, 1.49] | 5 studies · 1033 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Proton pump inhibitors plus prokinetics compared to prokinetics alone for functional dyspepsia
Population: adults with functional dyspepsia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global symptoms of dyspepsia Proton pump inhibitors plus prokinetics vs prokinetics alone | RR 0.85 [0.68, 1.08] | 2 studies · 407 participants | Moderate Downgraded: imprecision |
Quality of life Korean version of the dyspepsia related Nepean Dyspepsia Index (0 to 99) and Functional Digestive Disorders Quality of Life questionnaire (FDDQL) scale Proton pump inhibitors plus prokinetics vs prokinetics alone | no estimate extracted | 1 study · 258 participants | Moderate Downgraded: imprecision |
Adverse events Proton pump inhibitors plus prokinetics vs prokinetics alone | RR 0.6 [0.39, 0.93] | 2 studies · 407 participants | Moderate Downgraded: imprecision |