Cochrane · systematic review · CD002095
Short‐term treatment with proton pump inhibitors, H2‐receptor antagonists and prokinetics for gastro‐oesophageal reflux disease‐like symptoms and endoscopy negative reflux disease
Sigterman, KE, van Pinxteren, B, Bonis, PA, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 33.3%Moderate 4 · 44.4%High 2 · 22.2%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
PPIs, H2RAs or prokinetics for heartburn remission in gastro‐oesophageal reflux disease‐like symptoms
Population: patients with heartburn remission in gastro‐oesophageal reflux disease‐like symptoms
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PPI versus placebo Symptomatic outcome measures | RR 0.37 [0.32, 0.44] | 2 studies · 760 participants | High |
H2RA versus placebo | RR 0.77 [0.6, 0.99] | 2 studies · 1013 participants | Moderate Downgraded: risk of bias |
Prokinetic versus placebo | no estimate extracted | 1 study · 322 participants | High |
PPI versus H2RA | RR 0.66 [0.6, 0.73] | 7 studies · 3147 participants | Moderate Downgraded: imprecision, inconsistency |
PPI versus prokinetic | RR 0.53 [0.32, 0.87] | 2 studies · 747 participants | Low Downgraded: risk of bias, imprecision |
PPIs, H2RAs or prokinetics for heartburn remission in endoscopy negative reflux disease
Population: patients with heartburn remission in endoscopy negative reflux disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PPI versus placebo | RR 0.71 [0.65, 0.78] | 10 studies · 3710 participants | Moderate Downgraded: inconsistency |
H2RA versus placebo | RR 0.84 [0.74, 0.95] | 2 studies · 514 participants | Moderate Downgraded: risk of bias |
PPI versus H2RA | RR 0.78 [0.62, 0.97] | 4 studies · 960 participants | Low Downgraded: risk of bias, inconsistency |
PPI versus prokinetic | RR 0.72 [0.56, 0.92] | 1 study · 302 participants | Low Downgraded: risk of bias |