Proton pump inhibitors (PPI) vs placebo
Proton pump inhibitors (PPI) probably leads to lower global symptoms of dyspepsia (> 2 weeks) compared with placebo (moderate certainty).
- RR 0.88 [0.82, 0.94]18 studies · 6172 participantsModerate
Proton pump inhibitors (PPI) probably leads to lower global symptoms of dyspepsia (> 2 weeks) compared with placebo (moderate certainty).
Proton pump inhibitors (PPI) showed no clear difference in adverse events compared with placebo (moderate certainty).
Proton pump inhibitors (PPI) showed no clear difference in global symptoms of dyspepsia compared with H2 receptor antagonists (H2RA) (low certainty).
Proton pump inhibitors (PPI) showed no clear difference in adverse events compared with H2 receptor antagonists (H2RA) (moderate certainty).
Proton pump inhibitors (PPI) may leads to lower global symptoms of dyspepsia compared with prokinetics (low certainty).
Proton pump inhibitors (PPI) showed no clear difference in adverse events compared with prokinetics (moderate certainty).
Proton pump inhibitors plus prokinetics showed no clear difference in global symptoms of dyspepsia compared with prokinetics alone (moderate certainty).
Proton pump inhibitors plus prokinetics probably leads to lower adverse events compared with prokinetics alone (moderate certainty).
Proton pump inhibitors showed no clear difference in clinically important upper GI bleeding compared with placebo or no prophylaxis (low certainty).
Proton pump inhibitors showed no clear difference in nosocomial pneumonia compared with placebo or no prophylaxis (low certainty).
Proton pump inhibitors showed no clear difference in all‐cause mortality in ICU compared with placebo or no prophylaxis (low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
PPI plus usual care may leads to lower exacerbation rate (participants with one or more) study duration: 12… compared with usual care alone or chronic obstructive pulmonary disease (low certainty).
The review found no eligible studies for this question.