Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

45 questions · 45 findings · 5 reviews

No studies found 7 · 15.6%GRADE not reported 1 · 2.2%Very low 1 · 2.2%Low 18 · 40%Moderate 16 · 35.6%High 2 · 4.4%

Proton pump inhibitors (PPI) vs placebo or no prophylaxis

Clinically important upper GI bleeding · people admitted to intensive care units

Proton pump inhibitors showed no clear difference in clinically important upper GI bleeding compared with placebo or no prophylaxis (low certainty).

1 finding from 1 review

PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease

Exacerbations · patients with chronic obstructive pulmonary disease

PPI plus usual care may leads to lower exacerbation rate (participants with one or more) study duration: 12… compared with usual care alone or chronic obstructive pulmonary disease (low certainty).

1 finding from 1 review