Findings

What do systematic reviews say?

7 questions · 8 findings · 2 reviews · Developmental, Psychosocial and Learning Problems · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 62.5%Moderate 3 · 37.5%High 0 · 0%

Probiotics vs placebo

Pain frequency or change in pain frequency · Children with recurrent abdominal pain

1 finding from 1 review

Dietary interventions for recurrent abdominal pain in childhood 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 523 participants
Low

Probiotics vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Children with recurrent abdominal pain

1 finding from 1 review

Dietary interventions for recurrent abdominal pain in childhood 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 575 participants
Low

Probiotics vs placebo

Relief of pain · Children with recurrent abdominal pain

Probiotics probably leads to higher improvement in pain: 0 to 3 months' postintervention Different… compared with placebo (moderate certainty).

2 findings from 1 review

Dietary interventions for recurrent abdominal pain in childhood 2017 · Cochrane Headline outcomes only
OR 1.63 [1.07, 2.47]
7 studies · 722 participants
Moderate
Dietary interventions for recurrent abdominal pain in childhood 2017 · Cochrane Headline outcomes only
OR 1.94 [1.1, 3.43]
2 studies · 224 participants
Moderate

Probiotics vs placebo

Improvement in pain: 0 to 3 months' postintervention Subgroup (irritable bowel syndrome) Different measures were used to assess improvement in pain, as above. · Children with recurrent abdominal pain

Probiotics probably leads to higher improvement in pain: 0 to 3 months' postintervention Subgroup… compared with placebo (moderate certainty).

1 finding from 1 review

Dietary interventions for recurrent abdominal pain in childhood 2017 · Cochrane Headline outcomes only
OR 3.01 [1.77, 5.13]
4 studies · 344 participants
Moderate

Prophylactic probiotics vs placebo

Occurrence of new cases of colic Measured by: Wessel/Rome III Criteria · infants without colic

Prophylactic probiotics showed no clear difference in occurrence of new cases of colic Measured by: Wessel/Rome III Criteria compared with placebo (low certainty).

1 finding from 1 review

Probiotics to prevent infantile colic 2019 · Cochrane Headline outcomes only
RR 0.46 [0.18, 1.19]
3 studies · 1148 participants
Low

Prophylactic probiotics vs placebo

Adverse effects Measured by: reporting · infants without colic

Prophylactic probiotics showed no clear difference in adverse effects Measured by: reporting compared with placebo (low certainty).

1 finding from 1 review

Probiotics to prevent infantile colic 2019 · Cochrane Headline outcomes only
RR 1.02 [0.14, 7.21]
6 studies · 1851 participants
Low

Prophylactic probiotics vs placebo

Crying time at completion Measured in: minutes/day · infants without colic

1 finding from 1 review

Probiotics to prevent infantile colic 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 707 participants
Low