Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,289 questions · 2,331 findings · 195 reviews · Pregnancy and Childbirth · Headline outcomes only

No studies found 480 · 20.6%GRADE not reported 288 · 12.4%Very low 467 · 20%Low 630 · 27%Moderate 338 · 14.5%High 128 · 5.5%

Technique of BP measurement: Korotkoff phase IV vs Korotkoff phase V to represent diastolic BP

Pre‐eclampsia · pregnant women with diastolic hypertension

Technique of BP measurement: Korotkoff phase IV showed no clear difference in pre‐eclampsia compared with korotkoff phase V to represent diastolic BP (low certainty).

1 finding from 1 review

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

Macrosomia · pregnant women with pre‐existing diabetes

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes macrosomia compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

1 finding from 1 review

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

Caesarean section 4 · pregnant women with pre‐existing diabetes

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes caesarean section 4 compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Hypertensive disorders of pregnancy: pre‐eclampsia · preventing gestational diabetes

Probiotics leads to higher hypertensive disorders of pregnancy (pre‐eclampsia) compared with placebo (high certainty).

1 finding from 1 review

Intervention not reported

Proteinuric pre‐eclampsia · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower proteinuric pre‐eclampsia (high certainty).

1 finding from 1 review

Intervention not reported

Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower pregnancy with serious adverse outcome (composite including maternal… (high certainty).

1 finding from 1 review