Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,550 questions · 1,617 findings · 161 reviews · Neonatal

No studies found 238 · 14.7%GRADE not reported 76 · 4.7%Very low 377 · 23.3%Low 567 · 35.1%Moderate 285 · 17.6%High 74 · 4.6%

Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention

Gestational age (preterm birth < 37 weeks) · preterm infants

Probiotics administered to pregnant women at risk of preterm birth showed no clear difference in preterm birth < 37 weeks' gestation compared with placebo or no intervention (low certainty).

1 finding from 1 review

Prebiotic vs no prebiotics

Incidence of hyperbilirubinaemia · Neonates, including term neonates (gestational age ≥ 37 weeks), late preterm neonates (35 to 37 weeks' gestation) and preterm neonates (<…

Feeding supplementation with prebiotics may leads to lower incidence of hyperbilirubinaemia compared with no prebiotics (low certainty).

1 finding from 1 review

Prebiotic vs no prebiotics

Treatment with phototherapy · Neonates, including term neonates (gestational age ≥ 37 weeks), late preterm neonates (35 to 37 weeks' gestation) and preterm neonates (<…

Feeding supplementation with prebiotics may leads to lower treatment with phototherapy compared with no prebiotics (low certainty).

1 finding from 1 review

Prebiotic vs no prebiotics

Neonatal mortality · Neonates, including term neonates (gestational age ≥ 37 weeks), late preterm neonates (35 to 37 weeks' gestation) and preterm neonates (<…

Feeding supplementation with prebiotics showed no clear difference in neonatal mortality compared with no prebiotics (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Respiratory failure post extubation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower respiratory failure postextubation compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Gastrointestinal perforation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in gastrointestinal perforation compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Necrotising enterocolitis · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in necrotising enterocolitis compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Chronic lung disease · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in chronic lung disease (oxygen supplementation at 36 weeks) compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review