What do systematic reviews say?

Parathyroidectomy vs observation

Parathyroidectomy probably leads to lower cure of PHPT compared with observation (moderate certainty).

• Parathyroidectomy for adults with primary hyperparathyroidism 2023 · Cochrane Headline outcomes only
  RR 0.04 [0.02, 0.08]
  8 studies · 333 participants
  Moderate

Parathyroidectomy vs observation

• Parathyroidectomy for adults with primary hyperparathyroidism 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 287 participants
  Very low

Parathyroidectomy vs observation

• Parathyroidectomy for adults with primary hyperparathyroidism 2023 · Cochrane Headline outcomes only
  3.35 [0.14, 78.6]
  4 studies · 168 participants
  Low

Parathyroidectomy vs observation

• Parathyroidectomy for adults with primary hyperparathyroidism 2023 · Cochrane Headline outcomes only
  2.11 [0.2, 22.6]
  2 studies · 133 participants
  Very low

Parathyroidectomy vs observation

• Parathyroidectomy for adults with primary hyperparathyroidism 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 195 participants
  Very low

Parathyroidectomy vs observation

Parathyroidectomy showed no clear difference in hospitalisation for hypercalcaemia, renal impairment or pancreatitis compared with observation (low certainty).

• Parathyroidectomy for adults with primary hyperparathyroidism 2023 · Cochrane Headline outcomes only
  RR 0.91 [0.2, 4.25]
  6 studies · 287 participants
  Low

Minimally invasive parathyroidectomy vs bilateral neck exploration

It is very uncertain whether minimally invasive parathyroidectomy changes success rate (eucalcaemia) (a) compared with bilateral neck exploration (very low certainty).

• Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative… 2020 · Cochrane Headline outcomes only
  RR 0.98 [0.94, 1.03]
  5 studies · 266 participants
  Very low

Minimally invasive parathyroidectomy vs bilateral neck exploration

Minimally invasive parathyroidectomy may leads to lower total incidence of perioperative adverse events (number) compared with bilateral neck exploration (low certainty).

• Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative… 2020 · Cochrane Headline outcomes only
  RR 0.5 [0.33, 0.76]
  5 studies · 236 participants
  Low

Minimally invasive parathyroidectomy vs bilateral neck exploration

• Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Minimally invasive parathyroidectomy vs bilateral neck exploration

• Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Minimally invasive parathyroidectomy vs bilateral neck exploration

• Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Minimally invasive parathyroidectomy vs bilateral neck exploration

• Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 171 participants
  Very low

Minimally invasive parathyroidectomy vs bilateral neck exploration

The review found no eligible studies for this question.

• Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found