evidence/gaps
Cochrane · systematic review · CD013035

Parathyroidectomy for adults with primary hyperparathyroidism

Pappachan, JM, Lahart, IM, Viswanath, AK, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 1 · 16.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Parathyroidectomy compared to observation in adults with primary hyperparathyroidism

Population: people with primary hyperparathyroidism
6 questions
OutcomeEffectEvidenceStatus / GRADE
Cure of PHPT
Parathyroidectomy vs observation
RR 0.04 [0.02, 0.08]8 studies · 333 participantsModerate
Downgraded: risk of bias
Morbidity related to PHPT
Parathyroidectomy vs observation
no estimate extracted5 studies · 287 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Serious adverse events
Parathyroidectomy vs observation
3.35 [0.14, 78.6]4 studies · 168 participantsLow
Downgraded: risk of bias, imprecision
All‐cause mortality
Parathyroidectomy vs observation
2.11 [0.2, 22.6]2 studies · 133 participantsVery low
Downgraded: risk of bias, imprecision
Health‐related quality of life
Parathyroidectomy vs observation
no estimate extracted3 studies · 195 participantsVery low
Downgraded: risk of bias, imprecision, indirectness
Hospitalisation for hypercalcaemia, renal impairment or pancreatitis
Parathyroidectomy vs observation
RR 0.91 [0.2, 4.25]6 studies · 287 participantsLow
Downgraded: risk of bias, imprecision