Findings

What do systematic reviews say?

92 questions · 97 findings · 9 reviews · Pain, Palliative and Supportive Care · Headline outcomes only

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No studies found 13 · 13.4%GRADE not reported 2 · 2.1%Very low 47 · 48.5%Low 19 · 19.6%Moderate 12 · 12.4%High 4 · 4.1%

Paracetamol 1000 mg vs placebo

Pain‐free at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Pain‐free at 1 hour · adults with episodic tension‐type headache

2 findings from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate
Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 1000 mg vs placebo

Use of rescue medication · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 1000 mg vs placebo

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Any adverse event · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 500 mg to 650 mg vs placebo

Pain‐free at 1 hour · adults with episodic tension‐type headache

The review found no eligible studies for this question.

2 findings from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol 500 mg to 650 mg vs placebo

Use of rescue medication · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Paracetamol 500 mg to 650 mg vs placebo

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Paracetamol 500 mg to 650 mg vs placebo

Any adverse event · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Paracetamol 500 mg to 650 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol 500 mg to 650 mg vs placebo

Pain‐free at 2 hours · adults with episodic tension‐type headache

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Lack of efficacy withdrawal · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Withdrawals due to adverse events · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Serious adverse events · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Deaths · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Paracetamol vs NSAIDs see footnote1 · patients with postoperative pain

It is very uncertain whether the intervention changes paracetamol vs NSAIDs see footnote1 (very low certainty).

1 finding from 1 review

Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain 2016 · Cochrane Headline outcomes only
RR 0.82 [0.66, 1.02]
3 studies · 212 participants
Very low

Intervention not reported

Paracetamol vs propacetamol see footnote1 · patients with postoperative pain

The intervention showed no clear difference in paracetamol vs propacetamol see footnote1 (low certainty).

1 finding from 1 review

Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain 2016 · Cochrane Headline outcomes only
RR 0.94 [0.73, 1.2]
3 studies · 361 participants
Low