Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

245 questions · 245 findings · 20 reviews · Public Health · Headline outcomes only

No studies found 55 · 22.4%GRADE not reported 26 · 10.6%Very low 92 · 37.6%Low 54 · 22%Moderate 18 · 7.3%High 0 · 0%

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Anaemia · general population of all age groups (including pregnant women) from any country, over two years of age

iron‐fortified wheat flour with or without other micronutrients added may leads to lower anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with wheat flour (no added iron) with the same other micronutrients added (low certainty).

1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Diarrhoea (three liquid stools in a single day) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Respiratory infections (as measured by trialists) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

All‐cause death (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Infection or inflammation at individual level (as measured by urinary neopterin, C‐reactive protein or alpha‐1‐acid glycoprotein variant A) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age

It is very uncertain whether iron‐fortified wheat flour with or without other micronutrients added changes iron deficiency (as defined by study authors, based on a biomarker… compared with wheat flour (no added iron) with the same other micronutrients added (very low certainty).

1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Diarrhoea (three liquid stools in a single day) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Respiratory infections (as measured by trialists) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

All‐cause death (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Infection or inflammation at individual level as measured by C‐reactive protein (CRP) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Anaemia · general population of all age groups (including pregnant women) from any country, over two years of age

It is very uncertain whether iron‐fortified wheat flour with other micronutrients added changes anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with unfortified wheat flour (no micronutrients added) (very low certainty).

1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age

Iron‐fortified wheat flour with other micronutrients added probably leads to lower iron deficiency (as defined by study authors, based on a biomarker… compared with unfortified wheat flour (no micronutrients added) (moderate certainty).

1 finding from 1 review

Intervention not reported

Anaemia Defined as haemoglobin (Hb) concentration < 11 g/dL Measured at after 6 months and 6 ‐ 12 months of intervention · General population

The intervention may leads to lower anaemia Defined as haemoglobin (Hb) concentration < 11 g/dL Measured… (low certainty).

1 finding from 1 review

Intervention not reported

Anaemia Anaemia was defined as a haemoglobin (Hb) concentration < 13 g/dL for boys and < 12 g/dL for girls Measured after 9 months of intervention · General population

It is very uncertain whether the intervention changes anaemia Anaemia was defined as a haemoglobin (Hb) concentration < 13… (very low certainty).

1 finding from 1 review