Findings

What do systematic reviews say?

15 questions · 15 findings · 3 reviews · Heart

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 9 · 60%Moderate 4 · 26.7%High 2 · 13.3%

Fresh frozen plasma vs no plasma

Blood loss in first 24 hours (neonates and paediatric cases) · Neonates, children and adults undergoing cardiovascular surgery

1 finding from 1 review

Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 138 participants
Low

Fresh frozen plasma vs no plasma

Red cell transfusion requirement in first 24 hours (neonates and paediatric cases) · Neonates, children and adults undergoing cardiovascular surgery

1 finding from 1 review

Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 110 participants
Low

Prophylactic levosimendan vs usual care

All‐cause mortality · paediatric patients following heart surgery

Prophylactic levosimendan showed no clear difference in mortality compared with standard treatment (low certainty).

1 finding from 1 review

Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
RR 0.47 [0.12, 1.82]
3 studies · 123 participants
Low

Prophylactic levosimendan vs usual care

Low cardiac output syndrome (LCOS) · paediatric patients following heart surgery

Prophylactic levosimendan showed no clear difference in low cardiac output syndrome (LCOS) compared with standard treatment (low certainty).

1 finding from 1 review

Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
RR 0.64 [0.39, 1.04]
2 studies · 83 participants
Low

Prophylactic levosimendan vs usual care

Duration of ICU stay · paediatric patients following heart surgery

1 finding from 1 review

Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 188 participants
Low

Prophylactic levosimendan vs usual care

Length of hospital stay · paediatric patients following heart surgery

1 finding from 1 review

Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 75 participants
Low

Prophylactic levosimendan vs usual care

Duration of mechanical ventilation · paediatric patients following heart surgery

1 finding from 1 review

Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 208 participants
Low

Prophylactic levosimendan vs usual care

Mechanical circulatory support or cardiac transplantation · paediatric patients following heart surgery

Prophylactic levosimendan showed no clear difference in mechanical circulatory support or cardiac transplantation compared with standard treatment (low certainty).

1 finding from 1 review

Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
RR 1.49 [0.19, 11.37]
2 studies · 60 participants
Low

Any glucocorticoid vs placebo

In‐hospital postoperative mortality · Children having heart surgery with cardiopulmonary bypass

Glucocorticoid showed no clear difference in in‐hospital postoperative mortality compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
RR 0.83 [0.33, 2.07]
5 studies · 313 participants
Moderate

Any glucocorticoid vs placebo

Duration of postoperative mechanical ventilation · Children having heart surgery with cardiopulmonary bypass

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 421 participants
High

Any glucocorticoid vs placebo

Length of postoperative ICU stay · Children having heart surgery with cardiopulmonary bypass

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 421 participants
High

Any glucocorticoid vs placebo

Length of postoperative hospital stay · Children having heart surgery with cardiopulmonary bypass

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 176 participants
Moderate

Any glucocorticoid vs placebo

Mortality within the longest · Children having heart surgery with cardiopulmonary bypass

Glucocorticoid showed no clear difference in all‐cause mortality at longest compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
RR 0.83 [0.33, 2.07]
5 studies · 313 participants
Moderate

Any glucocorticoid vs placebo

Cardiovascular mortality · Children having heart surgery with cardiopulmonary bypass

Glucocorticoid showed no clear difference in cardiovascular mortality at longest compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
RR 0.4 [0.07, 2.46]
3 studies · 109 participants
Moderate

Any glucocorticoid vs placebo

Failure to separate from CPB · Children having heart surgery with cardiopulmonary bypass

Glucocorticoid showed no clear difference in failure to separate from CPB compared with placebo (low certainty).

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
RR 0.2 [0.01, 3.92]
1 study · 40 participants
Low