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What do systematic reviews say?

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Evidence found and GRADE certainty

360 questions · 370 findings · 102 reviews · Headline outcomes only

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No studies found 48 · 13%GRADE not reported 12 · 3.2%Very low 76 · 20.5%Low 121 · 32.7%Moderate 84 · 22.7%High 29 · 7.8%

Oxygen vs air

All‐cause mortality in hospital for participants with AMI · patients with acute myocardial infarction

It is very uncertain whether oxygen changes all‐cause mortality in hospital for participants with AMI compared with air (very low certainty).

1 finding from 1 review

Oxygen vs air

All‐cause mortality in hospital for all participants (including those without confirmed AMI) · patients with acute myocardial infarction

It is very uncertain whether oxygen changes all‐cause mortality in hospital for all participants (including… compared with air (very low certainty).

1 finding from 1 review

Oxygen vs air

All‐cause mortality in hospital for all participants (including those without confirmed AMI) trials done in the revascularisation era · patients with acute myocardial infarction

Oxygen showed no clear difference in all‐cause mortality in hospital for all participants (including… compared with air (low certainty).

1 finding from 1 review

Oxygen vs air

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · patients with acute myocardial infarction

Oxygen showed no clear difference in opiate use (as a proxy measure for pain) for all participants on ITT… compared with air (low certainty).

1 finding from 1 review

Oxygen vs air

Recurrent myocardial infarction (or ischaemia) · patients with acute myocardial infarction

Oxygen showed no clear difference in recurrent myocardial infarction (or ischaemia) compared with air (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Incidence of severe hypoxaemia (SpO2 < 80%) · people requiring tracheal intubation

Oxygenation showed no clear difference in incidence of severe hypoxaemia (SpO2 < 80%) compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Hypoxaemia · people requiring tracheal intubation

Oxygenation showed no clear difference in incidence of hypoxaemia (SpO2 < 93%) compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

First‐pass success of cannulation · people requiring tracheal intubation

Oxygenation showed no clear difference in first pass success rate compared with no oxygenation during the apnoeic period preceding intubation (moderate certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

All‐cause mortality · people requiring tracheal intubation

Oxygenation showed no clear difference in mortality compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Titrated oxygen therapy vs high‐flow oxygen therapy

Mortality (respiratory‐ related and all‐cause · adults with acute exacerbations of chronic obstructive pulmonary disease

Titrated oxygen therapy may leads to lower mortality (respiratory‐ related and all‐cause compared with high‐flow oxygen therapy (low certainty).

1 finding from 1 review

Titrated oxygen therapy vs high‐flow oxygen therapy

Ventilation of any type · adults with acute exacerbations of chronic obstructive pulmonary disease

Titrated oxygen therapy showed no clear difference in ventilation of any type compared with high‐flow oxygen therapy (low certainty).

1 finding from 1 review