Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 10 findings · 1 reviews · Gut

No studies found 0 · 0%GRADE not reported 2 · 20%Very low 0 · 0%Low 5 · 50%Moderate 3 · 30%High 0 · 0%

Oral ondansetron (weight based) vs placebo

Rate of admission during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to lower rate of admission during ED stay compared with placebo (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of admission 72 hrs · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) showed no clear difference in rate of admission 72 hrs compared with placebo (low certainty).

2 findings from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to lower rate of intravenous rehydration during ED stay compared with placebo (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration up to 72 hrs following discharge from ED (best ‐ worst scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration up to 72 hrs following discharge from ED (worst ‐ best scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Proportion of patients with cessation of vomiting · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to higher proportion of patients with cessation of vomiting compared with placebo (moderate certainty).

1 finding from 1 review