Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

801 questions · 875 findings · 91 reviews

No studies found 182 · 20.8%GRADE not reported 220 · 25.1%Very low 229 · 26.2%Low 128 · 14.6%Moderate 76 · 8.7%High 40 · 4.6%

Older age vs Younger adults (population mean age <=33.4 years)

Oral health-related quality of life · Adolescents (10-19 years)

The abstract reports older age is associated with worse OHRQoL, but the body notes the evidence on age is limited and conflicting (narrative synthesis; no pooled estimate or GRADE rating).

2 findings from 1 review

Older adults (population mean age >33.4 years) vs Younger adults (population mean age <=33.4 years)

Caries experience (mean DMFT) · Adults aged 19-60 years

Studies of older adults (mean age >33.4 years) had higher pooled DMFT than younger adults, but the age to DMFT meta-regression was not statistically significant; ungraded observational evidence.

5 findings from 1 review
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Older child age (months) vs Younger age (reference)

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Age 48-59 months was associated with higher odds of ECC (OR 2.602).

2 findings from 1 review

Sociodemographic and behavioural factors (older age, lower education, lower income, poor oral hygiene/brushing, smoking, disadvantaged/slum residence, sex) vs Referent groups (younger, higher education/income, better oral hygiene, non-slum residence)

Determinants of oral diseases · Adult residents of slums and non-slum urban settings of LMICs

Age, education, income, oral-hygiene behaviour, dental-visit pattern and slum/disadvantaged residence are associated with oral disease; gender effects are disease-specific; ungraded.

1 finding from 1 review

Case management for integrated care vs usual care of older people living with frailty

All‐cause mortality · people aged 65 years and older living with frailty

Case management for integrated care showed no clear difference in mortality compared with usual care of older people living with frailty (low certainty).

1 finding from 1 review

Case management for integrated care vs usual care of older people living with frailty

Change in place of residence to a nursing or residential home · people aged 65 years and older living with frailty

Case management for integrated care showed no clear difference in change in place of residence to a nursing or residential home compared with usual care of older people living with frailty (low certainty).

1 finding from 1 review

Case management for integrated care vs usual care of older people living with frailty

Change in healthcare utilisation (hospital admissions) · people aged 65 years and older living with frailty

Case management for integrated care showed no clear difference in change in healthcare utilisation (hospital admissions) compared with usual care of older people living with frailty (moderate certainty).

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Death from any cause · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

It is very uncertain whether long‐stored ('older') PRBC (≥ 21 days of storage) changes death from any cause compared with short‐stored (fresh) PRBC (< 21 days of storage) (very low certainty).

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Transfusion‐related acute lung injury ‐ not measured · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

The review found no eligible studies for this question.

1 finding from 1 review