Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 3 reviews · Emergency and Critical Care · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 7.1%Low 5 · 35.7%Moderate 8 · 57.1%High 0 · 0%

Intervention not reported

Requirement for renal replacement therapy ( · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes requirement for renal replacement therapy ( (very low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Catheter‐related BSI as defined using criteria specified by Maki 2006; Mermel 2009; and O'Grady 2002 · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in catheter‐related BSI as defined using criteria specified by Maki… compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Infusate‐related BSI as defined using criteria specified by O'Grady 2002 · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in infusate‐related BSI as defined using criteria specified by O'Grady… compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Infusate colonization any positive quantitative culture of infusate · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in infusate colonization any positive quantitative culture of infusate compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Catheter colonization any positive semiquantitative or quantitative culture from the distal catheter segment · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in catheter colonization any positive semiquantitative or quantitative… compared with more frequent (moderate certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

All‐cause BSI any positive blood culture drawn from a peripheral vein taken whilst the IVD is in situ, or within 48 hours of removal (O'Grady 2002) · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in all‐cause BSI any positive blood culture drawn from a peripheral… compared with more frequent (low certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related infectious complications ‐ Catheter colonization · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in catheter‐related infectious complications ‐ Catheter colonization compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related blood stream infection · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in catheter‐related infectious complications ‐ Catheter related… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related infectious complication ‐ Subgroup Analysis for the effect of BMI on catheter colonization ‐ Highest BMI tercile (>28.4) · critically ill patients who were expected to require support with renal replacement therapy

Femoral probably leads to higher catheter‐related infectious complication ‐ Subgroup Analysis for the… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related thrombotic complications ‐ Symptomatic deep venous thrombosis · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in catheter‐related thrombotic complications ‐ Symptomatic deep venous… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related thrombosis at any time during catheter stay · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in catheter‐related thrombotic complications ‐ Catheter related… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Immediate mechanical complications ‐ Total mechanical complications · critically ill patients who were expected to require support with renal replacement therapy

Femoral probably leads to lower immediate mechanical complications ‐ Total mechanical complications compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Immediate mechanical complications ‐ Major mechanical complications · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in immediate mechanical complications ‐ Major mechanical complications compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review