Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

49 questions · 53 findings · 6 reviews

No studies found 1 · 1.9%GRADE not reported 6 · 11.3%Very low 11 · 20.8%Low 23 · 43.4%Moderate 12 · 22.6%High 0 · 0%

HFNC vs NIPPV or NIV

Treatment failure (escalation of respiratory therapy to NIV, NIPPV or invasive ventilation) Measured up to 28 days · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with NIPPV or NIV (low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Duration of tachypnea, defined as hours with respiratory rate greater than 60 breaths per minute · patients with the management of transient tachypnea of the newborn
2 findings from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Need for mechanical ventilation · patients with the management of transient tachypnea of the newborn

It is very uncertain whether CPAP changes need for mechanical ventilation ‒NIPPV versus CPAP compared with nasal ventilation (NIPPV or NHFV) (very low certainty).

2 findings from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Pneumothorax · patients with the management of transient tachypnea of the newborn

It is very uncertain whether CPAP changes pneumothorax ‒NIPPV versus CPAP compared with nasal ventilation (NIPPV or NHFV) (very low certainty).

2 findings from 1 review

NIPPV vs NCPAP

Respiratory failure post extubation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower respiratory failure postextubation compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Gastrointestinal perforation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in gastrointestinal perforation compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Necrotising enterocolitis · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in necrotising enterocolitis compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Chronic lung disease · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in chronic lung disease (oxygen supplementation at 36 weeks) compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Mortality before hospital discharge · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in mortality (defined as death before discharge) compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Need for endotracheal tube ventilation · )

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower need for endotracheal tube ventilation compared with nasal continuous positive airway pressure (NCPAP) (by population) (moderate certainty).

1 finding from 1 review